BDBM2259 2-Pyridinone derivative 39::3-{[(4,7-Dichlorobenzoxazol-2-yl)methyl]sulfonyl}-5-ethyl-6-methylpyridin-2(1H)-one::3-{[(4,7-dichloro-1,3-benzoxazol-2-yl)methane]sulfonyl}-5-ethyl-6-methyl-1,2-dihydropyridin-2-one::CHEMBL176637

SMILES: CCc1cc(c(=O)[nH]c1C)S(=O)(=O)Cc1nc2c(Cl)ccc(Cl)c2o1

InChI Key: InChIKey=PUZKWXILSRLVLO-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 2259   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1)	BDBM2259 (2-Pyridinone derivative 39 | 3-{[(4,7-Dichlorobenz...) Show SMILES CCc1cc(c(=O)[nH]c1C)S(=O)(=O)Cc1nc2c(Cl)ccc(Cl)c2o1 Show InChI InChI=1S/C16H14Cl2N2O4S/c1-3-9-6-12(16(21)19-8(9)2)25(22,23)7-13-20-14-10(17)4-5-11(18)15(14)24-13/h4-6H,3,7H2,1-2H3,(H,19,21)	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	205	n/a	n/a	n/a	n/a	n/a	n/a
Merck Reserch Laboratories Curated by ChEMBL					Assay Description Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)				J Med Chem 36: 953-66 (1993) BindingDB Entry DOI: 10.7270/Q2JW8G28
					More data for this Ligand-Target Pair
HIV-1 Reverse Transcriptase (Human immunodeficiency virus type 1)	BDBM2259 (2-Pyridinone derivative 39 | 3-{[(4,7-Dichlorobenz...) Show SMILES CCc1cc(c(=O)[nH]c1C)S(=O)(=O)Cc1nc2c(Cl)ccc(Cl)c2o1 Show InChI InChI=1S/C16H14Cl2N2O4S/c1-3-9-6-12(16(21)19-8(9)2)25(22,23)7-13-20-14-10(17)4-5-11(18)15(14)24-13/h4-6H,3,7H2,1-2H3,(H,19,21)	PDB MMDB B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	205	n/a	n/a	n/a	n/a	n/a	n/a
Merck Reserch Laboratories Curated by ChEMBL					Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.				J Med Chem 36: 953-66 (1993) BindingDB Entry DOI: 10.7270/Q2JW8G28
					More data for this Ligand-Target Pair