BDBM226458 US9328096, 151

SMILES: Nc1ccc(CNC(=O)c2cc(NC(=O)c3cc(c(F)cc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)cn1

InChI Key: InChIKey=WIOBEOQJKWIGQL-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 226458   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine kinase receptor A (TrkA) (Homo sapiens (Human))	BDBM226458 (US9328096, 151) Show SMILES Nc1ccc(CNC(=O)c2cc(NC(=O)c3cc(c(F)cc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)cn1 Show InChI InChI=1S/C28H20ClF2N7O2/c29-20-12-22(31)19(26-21(30)7-4-10-33-26)11-18(20)27(39)36-25-13-23(37-38(25)17-5-2-1-3-6-17)28(40)35-15-16-8-9-24(32)34-14-16/h1-14H,15H2,(H2,32,34)(H,35,40)(H,36,39)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.98	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...				US Patent US9328096 (2016) BindingDB Entry DOI: 10.7270/Q2FN152J
					More data for this Ligand-Target Pair