new BindingDB logo
myBDB logout

BDBM226483 US9328096, 176

SMILES: Fc1ccc(nc1)-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCc2cn[nH]c2)c(Cl)cc1Cl

InChI Key: InChIKey=GPYHATKQXSOGBR-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 226483   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine kinase receptor A (TrkA)


(Homo sapiens (Human))
BDBM226483
PNG
(US9328096, 176)
Show SMILES Fc1ccc(nc1)-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCc2cn[nH]c2)c(Cl)cc1Cl
Show InChI InChI=1S/C26H18Cl2FN7O2/c27-20-9-21(28)19(8-18(20)22-7-6-16(29)14-30-22)25(37)34-24-10-23(26(38)31-11-15-12-32-33-13-15)35-36(24)17-4-2-1-3-5-17/h1-10,12-14H,11H2,(H,31,38)(H,32,33)(H,34,37)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.60n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...


US Patent US9328096 (2016)


BindingDB Entry DOI: 10.7270/Q2FN152J
More data for this
Ligand-Target Pair