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BDBM226527 US9328096, 220

SMILES: Cc1n[nH]c(C)c1NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1

InChI Key: InChIKey=BVWGMIMXCDLZGU-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 226527   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine kinase receptor A (TrkA)


(Homo sapiens (Human))
BDBM226527
PNG
(US9328096, 220)
Show SMILES Cc1n[nH]c(C)c1NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1
Show InChI InChI=1S/C27H21Cl2N7O2/c1-15-25(16(2)34-33-15)32-27(38)23-14-24(36(35-23)17-8-4-3-5-9-17)31-26(37)19-12-18(20(28)13-21(19)29)22-10-6-7-11-30-22/h3-14H,1-2H3,(H,31,37)(H,32,38)(H,33,34)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.71n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...


US Patent US9328096 (2016)


BindingDB Entry DOI: 10.7270/Q2FN152J
More data for this
Ligand-Target Pair