BDBM22675 Bicyclic pyrimidinone, 12a::N-[(4-fluorophenyl)methyl]-3-hydroxy-4-oxo-4H,6H,7H,8H-pyrrolo[1,2-a]pyrimidine-2-carboxamide

SMILES: Oc1c(nc2CCCn2c1=O)C(=O)NCc1ccc(F)cc1

InChI Key: InChIKey=XHEKDFUSKMFJIZ-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 22675   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...)	BDBM22675 (Bicyclic pyrimidinone, 12a | N-[(4-fluorophenyl)me...) Show SMILES Oc1c(nc2CCCn2c1=O)C(=O)NCc1ccc(F)cc1 Show InChI InChI=1S/C15H14FN3O3/c16-10-5-3-9(4-6-10)8-17-14(21)12-13(20)15(22)19-7-1-2-11(19)18-12/h3-6,20H,1-2,7-8H2,(H,17,21)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	7.8	37
IRBM-MRL					Assay Description The microtiter plate assay for stand transfer was performed with an immobilized donor substrate and a target substrate biotinylated at the 3-prime en...				J Med Chem 51: 861-74 (2008) Article DOI: 10.1021/jm701164t BindingDB Entry DOI: 10.7270/Q2765CNT
					More data for this Ligand-Target Pair