BDBM226759 US9328096, 452

SMILES: Nc1cc(CNC(=O)c2cc(NC(=O)c3cc(c(Cl)cc3Cl)-c3ccc(F)cn3)n(n2)-c2ccccc2)ccn1

InChI Key: InChIKey=KXURWBDZXKSKIF-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 226759   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine kinase receptor A (TrkA) (Homo sapiens (Human))	BDBM226759 (US9328096, 452) Show SMILES Nc1cc(CNC(=O)c2cc(NC(=O)c3cc(c(Cl)cc3Cl)-c3ccc(F)cn3)n(n2)-c2ccccc2)ccn1 Show InChI InChI=1S/C28H20Cl2FN7O2/c29-21-12-22(30)20(11-19(21)23-7-6-17(31)15-34-23)27(39)36-26-13-24(37-38(26)18-4-2-1-3-5-18)28(40)35-14-16-8-9-33-25(32)10-16/h1-13,15H,14H2,(H2,32,33)(H,35,40)(H,36,39)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.43	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...				US Patent US9328096 (2016) BindingDB Entry DOI: 10.7270/Q2FN152J
					More data for this Ligand-Target Pair