BDBM226850 US9328096, 543

SMILES: O[C@H]1C[C@@H](C1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1

InChI Key: InChIKey=HAXIQZOJDSDNAT-KOMQPUFPSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 226850   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine kinase receptor A (TrkA) (Homo sapiens (Human))	BDBM226850 (US9328096, 543) Show SMILES O[C@H]1C[C@@H](C1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 |wU:3.5,wD:1.0,(-5.13,-2.63,;-5.13,-1.09,;-4.04,-0,;-5.13,1.09,;-6.22,-0,;-5.13,2.63,;-3.8,3.4,;-3.8,4.94,;-2.46,2.63,;-2.3,1.09,;-.79,.77,;-.17,-.63,;-1.07,-1.88,;-2.6,-1.72,;-.45,-3.29,;-1.35,-4.53,;-.73,-5.94,;.81,-6.1,;1.43,-7.51,;1.71,-4.85,;1.08,-3.45,;1.99,-2.2,;-1.63,-7.18,;-3.16,-7.02,;-4.07,-8.27,;-3.44,-9.68,;-1.91,-9.84,;-1,-8.59,;.53,-8.75,;-.02,2.11,;-1.06,3.25,;1.51,2.27,;2.13,3.68,;3.66,3.84,;4.57,2.59,;3.94,1.18,;2.41,1.02,)| Show InChI InChI=1S/C26H20Cl2FN5O3/c27-19-12-20(28)18(11-17(19)24-21(29)7-4-8-30-24)25(36)32-23-13-22(26(37)31-14-9-16(35)10-14)33-34(23)15-5-2-1-3-6-15/h1-8,11-14,16,35H,9-10H2,(H,31,37)(H,32,36)/t14-,16-	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.69	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...				US Patent US9328096 (2016) BindingDB Entry DOI: 10.7270/Q2FN152J
					More data for this Ligand-Target Pair