BDBM226853 US9328096, 546

SMILES: OCC1(CNC(=O)c2cc(NC(=O)c3cc(c(Cl)cc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)COC1

InChI Key: InChIKey=XCTBJCRSZHUPEU-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 226853   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine kinase receptor A (TrkA) (Homo sapiens (Human))	BDBM226853 (US9328096, 546) Show SMILES OCC1(CNC(=O)c2cc(NC(=O)c3cc(c(Cl)cc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)COC1 Show InChI InChI=1S/C27H22Cl2FN5O4/c28-19-10-20(29)18(9-17(19)24-21(30)7-4-8-31-24)25(37)33-23-11-22(34-35(23)16-5-2-1-3-6-16)26(38)32-12-27(13-36)14-39-15-27/h1-11,36H,12-15H2,(H,32,38)(H,33,37)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.14	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...				US Patent US9328096 (2016) BindingDB Entry DOI: 10.7270/Q2FN152J
					More data for this Ligand-Target Pair