BDBM226862 US9328096, 555

SMILES: Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)N[C@@H]2CCOC2)c(Cl)cc1Cl

InChI Key: InChIKey=AADGFLAQHXJJRJ-OAHLLOKOSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 226862   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine kinase receptor A (TrkA) (Homo sapiens (Human))	BDBM226862 (US9328096, 555) Show SMILES Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)N[C@@H]2CCOC2)c(Cl)cc1Cl Show InChI InChI=1S/C26H20Cl2FN5O3/c27-19-12-20(28)18(11-17(19)24-21(29)7-4-9-30-24)25(35)32-23-13-22(26(36)31-15-8-10-37-14-15)33-34(23)16-5-2-1-3-6-16/h1-7,9,11-13,15H,8,10,14H2,(H,31,36)(H,32,35)/t15-/m1/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.41	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...				US Patent US9328096 (2016) BindingDB Entry DOI: 10.7270/Q2FN152J
					More data for this Ligand-Target Pair