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BDBM226877 US9328096, 570

SMILES: C[C@@H](CO)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1

InChI Key: InChIKey=SGUXWMRNTMGMMJ-AWEZNQCLSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 226877   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine kinase receptor A (TrkA)


(Homo sapiens (Human))
BDBM226877
PNG
(US9328096, 570)
Show SMILES C[C@@H](CO)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1
Show InChI InChI=1S/C25H20Cl2FN5O3/c1-14(13-34)30-25(36)21-12-22(33(32-21)15-6-3-2-4-7-15)31-24(35)17-10-16(18(26)11-19(17)27)23-20(28)8-5-9-29-23/h2-12,14,34H,13H2,1H3,(H,30,36)(H,31,35)/t14-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.73n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...


US Patent US9328096 (2016)


BindingDB Entry DOI: 10.7270/Q2FN152J
More data for this
Ligand-Target Pair