BDBM226881 US9328096, 574

SMILES: Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCc2ccno2)c(Cl)cc1Cl

InChI Key: InChIKey=LOTSADQJYRXQTO-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 226881   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine kinase receptor A (TrkA) (Homo sapiens (Human))	BDBM226881 (US9328096, 574) Show SMILES Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCc2ccno2)c(Cl)cc1Cl Show InChI InChI=1S/C26H17Cl2FN6O3/c27-19-12-20(28)18(11-17(19)24-21(29)7-4-9-30-24)25(36)33-23-13-22(26(37)31-14-16-8-10-32-38-16)34-35(23)15-5-2-1-3-6-15/h1-13H,14H2,(H,31,37)(H,33,36)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.46	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...				US Patent US9328096 (2016) BindingDB Entry DOI: 10.7270/Q2FN152J
					More data for this Ligand-Target Pair