BDBM226999 US9328096, 687

SMILES: Oc1ccc(CNC(=O)c2cc(NC(=O)c3cc(c(F)cc3Cl)-c3ccccn3)n(n2)-c2ccccc2)nc1

InChI Key: InChIKey=SWILKFWGVKOEON-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 226999   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine kinase receptor A (TrkA) (Homo sapiens (Human))	BDBM226999 (US9328096, 687) Show SMILES Oc1ccc(CNC(=O)c2cc(NC(=O)c3cc(c(F)cc3Cl)-c3ccccn3)n(n2)-c2ccccc2)nc1 Show InChI InChI=1S/C28H20ClFN6O3/c29-22-13-23(30)21(24-8-4-5-11-31-24)12-20(22)27(38)34-26-14-25(35-36(26)18-6-2-1-3-7-18)28(39)33-15-17-9-10-19(37)16-32-17/h1-14,16,37H,15H2,(H,33,39)(H,34,38)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.27	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...				US Patent US9328096 (2016) BindingDB Entry DOI: 10.7270/Q2FN152J
					More data for this Ligand-Target Pair