BDBM227330 US9328106, 281

SMILES: CO[C@H]1CO[C@@H](CC[C@H]1N)c1c(NC(=O)c2nc(sc2N)-c2cc(Cl)ccc2F)cnn1C

InChI Key: InChIKey=RPZQNUBZVSZLDG-KBMXLJTQSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 227330   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM227330 (US9328106, 281) Show SMILES CO[C@H]1CO[C@@H](CC[C@H]1N)c1c(NC(=O)c2nc(sc2N)-c2cc(Cl)ccc2F)cnn1C |r| Show InChI InChI=1S/C21H24ClFN6O3S/c1-29-18(15-6-5-13(24)16(31-2)9-32-15)14(8-26-29)27-20(30)17-19(25)33-21(28-17)11-7-10(22)3-4-12(11)23/h3-4,7-8,13,15-16H,5-6,9,24-25H2,1-2H3,(H,27,30)/t13-,15+,16+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.00700	-15.2	n/a	n/a	n/a	n/a	n/a	7.2	25
GENENTECH, INC. US Patent					Assay Description LC3K assay: PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Ch...				US Patent US9328106 (2016) BindingDB Entry DOI: 10.7270/Q29W0DBT
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