BDBM227381 US9328106, 332

SMILES: Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)ccc(F)c2F)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1

InChI Key: InChIKey=KVYQPSVHULBNGT-WZRBSPASSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 227381   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM227381 (US9328106, 332) Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)ccc(F)c2F)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 |r| Show InChI InChI=1S/C20H20F4N6O2S/c1-30-17(13-5-4-11(25)10(23)7-32-13)12(6-27-30)28-19(31)16-18(26)33-20(29-16)14-8(21)2-3-9(22)15(14)24/h2-3,6,10-11,13H,4-5,7,25-26H2,1H3,(H,28,31)/t10-,11-,13+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.00300	-15.7	n/a	n/a	n/a	n/a	n/a	7.2	25
GENENTECH, INC. US Patent					Assay Description LC3K assay: PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Ch...				US Patent US9328106 (2016) BindingDB Entry DOI: 10.7270/Q29W0DBT
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