BDBM227793 8-[(4,4-Dimethylpiperidin-1-yl)methyl]-4-[(2-fluoro-5-hydroxy-4-methylphenyl)amino]-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one::US10047096, 56

SMILES: Cc1cc(F)c(Nc2ccnc3Nc4ccc(CN5CCC(C)(C)CC5)cc4NC(=O)c23)cc1O

InChI Key: InChIKey=HJRLGIHYFRRZGA-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 227793   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM227793 (8-[(4,4-Dimethylpiperidin-1-yl)methyl]-4-[(2-fluor...) Show SMILES Cc1cc(F)c(Nc2ccnc3Nc4ccc(CN5CCC(C)(C)CC5)cc4NC(=O)c23)cc1O Show InChI InChI=1S/C27H30FN5O2/c1-16-12-18(28)21(14-23(16)34)30-20-6-9-29-25-24(20)26(35)32-22-13-17(4-5-19(22)31-25)15-33-10-7-27(2,3)8-11-33/h4-6,9,12-14,34H,7-8,10-11,15H2,1-3H3,(H,32,35)(H2,29,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.49	n/a	n/a	n/a	n/a	7.5	22
Bayer Pharma Aktiengesellschaft US Patent					Assay Description The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human PDGFRβ (amino acids R561-L1106), expr...				US Patent US10047096 (2018) BindingDB Entry DOI: 10.7270/Q23R0VW4
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM227793 (8-[(4,4-Dimethylpiperidin-1-yl)methyl]-4-[(2-fluor...) Show SMILES Cc1cc(F)c(Nc2ccnc3Nc4ccc(CN5CCC(C)(C)CC5)cc4NC(=O)c23)cc1O Show InChI InChI=1S/C27H30FN5O2/c1-16-12-18(28)21(14-23(16)34)30-20-6-9-29-25-24(20)26(35)32-22-13-17(4-5-19(22)31-25)15-33-10-7-27(2,3)8-11-33/h4-6,9,12-14,34H,7-8,10-11,15H2,1-3H3,(H,32,35)(H2,29,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.595	n/a	n/a	n/a	n/a	7.0	n/a
Bayer Pharma Aktiengesellschaft US Patent					Assay Description The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...				US Patent US10047096 (2018) BindingDB Entry DOI: 10.7270/Q23R0VW4
					More data for this Ligand-Target Pair