BDBM227813 US10047096, 75::rac-4-[(2-Fluoro-5-hydroxy-4-methylphenyl)amino]-8-{[(1-hydroxy-3-methylbutan-2-yl)amino]methyl}-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one

SMILES: CC(C)C(CO)NCc1ccc2Nc3nccc(Nc4cc(O)c(C)cc4F)c3C(=O)Nc2c1

InChI Key: InChIKey=AQGHUQFARNGYDN-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 227813   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM227813 (US10047096, 75 | rac-4-[(2-Fluoro-5-hydroxy-4-meth...) Show SMILES CC(C)C(CO)NCc1ccc2Nc3nccc(Nc4cc(O)c(C)cc4F)c3C(=O)Nc2c1 Show InChI InChI=1S/C25H28FN5O3/c1-13(2)21(12-32)28-11-15-4-5-17-20(9-15)31-25(34)23-18(6-7-27-24(23)30-17)29-19-10-22(33)14(3)8-16(19)26/h4-10,13,21,28,32-33H,11-12H2,1-3H3,(H,31,34)(H2,27,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.826	n/a	n/a	n/a	n/a	7.5	22
Bayer Pharma Aktiengesellschaft US Patent					Assay Description The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human PDGFRβ (amino acids R561-L1106), expr...				US Patent US10047096 (2018) BindingDB Entry DOI: 10.7270/Q23R0VW4
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM227813 (US10047096, 75 | rac-4-[(2-Fluoro-5-hydroxy-4-meth...) Show SMILES CC(C)C(CO)NCc1ccc2Nc3nccc(Nc4cc(O)c(C)cc4F)c3C(=O)Nc2c1 Show InChI InChI=1S/C25H28FN5O3/c1-13(2)21(12-32)28-11-15-4-5-17-20(9-15)31-25(34)23-18(6-7-27-24(23)30-17)29-19-10-22(33)14(3)8-16(19)26/h4-10,13,21,28,32-33H,11-12H2,1-3H3,(H,31,34)(H2,27,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.706	n/a	n/a	n/a	n/a	7.0	n/a
Bayer Pharma Aktiengesellschaft US Patent					Assay Description The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...				US Patent US10047096 (2018) BindingDB Entry DOI: 10.7270/Q23R0VW4
					More data for this Ligand-Target Pair