BDBM227830 4-[(2-Fluoro-5-hydroxy-4-methylphenyl)amino]-8-({3-hydroxy-4-[(2-hydroxyethyl)amino]pyrrolidin-1-yl}methyl)-6,11-dihydro-5H-pyrido[2, 3-b][1,5]benzodiazepin-5-one::US10047096, 91
SMILES: Cc1cc(F)c(Nc2ccnc3Nc4ccc(CN5CC(O)C(C5)NCCO)cc4NC(=O)c23)cc1O
InChI Key: InChIKey=ZNKAHOBYOWIVNF-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Platelet-derived growth factor receptor beta (Homo sapiens (Human)) | BDBM227830 (4-[(2-Fluoro-5-hydroxy-4-methylphenyl)amino]-8-({3...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.66 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Bayer Pharma Aktiengesellschaft US Patent | Assay Description The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human PDGFRβ (amino acids R561-L1106), expr... | US Patent US10047096 (2018) BindingDB Entry DOI: 10.7270/Q23R0VW4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM227830 (4-[(2-Fluoro-5-hydroxy-4-methylphenyl)amino]-8-({3...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.522 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Bayer Pharma Aktiengesellschaft US Patent | Assay Description The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse... | US Patent US10047096 (2018) BindingDB Entry DOI: 10.7270/Q23R0VW4 | |||||||||||
More data for this Ligand-Target Pair |