BDBM227949 8-{[(3,4-cis-Dihydroxypyrrolidin-1-yl]methyl}-4-[(2-fluoro-5-hydroxy-4-methylphenyl)amino]-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one::US10047096, 210

SMILES: Cc1cc(F)c(Nc2ccnc3Nc4ccc(CN5C[C@H](O)[C@H](O)C5)cc4NC(=O)c23)cc1O

InChI Key: InChIKey=JQWRPCZUMWGJSB-OYRHEFFESA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 227949   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM227949 (8-{[(3,4-cis-Dihydroxypyrrolidin-1-yl]methyl}-4-[(...) Show SMILES Cc1cc(F)c(Nc2ccnc3Nc4ccc(CN5C[C@H](O)[C@H](O)C5)cc4NC(=O)c23)cc1O |r| Show InChI InChI=1S/C24H24FN5O4/c1-12-6-14(25)17(8-19(12)31)27-16-4-5-26-23-22(16)24(34)29-18-7-13(2-3-15(18)28-23)9-30-10-20(32)21(33)11-30/h2-8,20-21,31-33H,9-11H2,1H3,(H,29,34)(H2,26,27,28)/t20-,21+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.03	n/a	n/a	n/a	n/a	7.5	22
Bayer Pharma Aktiengesellschaft US Patent					Assay Description The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human PDGFRβ (amino acids R561-L1106), expr...				US Patent US10047096 (2018) BindingDB Entry DOI: 10.7270/Q23R0VW4
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM227949 (8-{[(3,4-cis-Dihydroxypyrrolidin-1-yl]methyl}-4-[(...) Show SMILES Cc1cc(F)c(Nc2ccnc3Nc4ccc(CN5C[C@H](O)[C@H](O)C5)cc4NC(=O)c23)cc1O |r| Show InChI InChI=1S/C24H24FN5O4/c1-12-6-14(25)17(8-19(12)31)27-16-4-5-26-23-22(16)24(34)29-18-7-13(2-3-15(18)28-23)9-30-10-20(32)21(33)11-30/h2-8,20-21,31-33H,9-11H2,1H3,(H,29,34)(H2,26,27,28)/t20-,21+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.578	n/a	n/a	n/a	n/a	7.0	n/a
Bayer Pharma Aktiengesellschaft US Patent					Assay Description The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...				US Patent US10047096 (2018) BindingDB Entry DOI: 10.7270/Q23R0VW4
					More data for this Ligand-Target Pair