BDBM228204 3-methyl-8-(6-(1-methyl-1H-pyrazol-4-yl)pyridin-3-yl)-1-(1-(methanesulfonyl)piperidin-3-yl)-1H-imidazo[4,5-c]quinolin-2(3H)-one::US10047084, 3::US10047084, 36

SMILES: Cn1cc(cn1)-c1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCCN(C4)S(C)(=O)=O)c3c2c1

InChI Key: InChIKey=VNVSMYNQNASCOA-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 228204   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM228204 (3-methyl-8-(6-(1-methyl-1H-pyrazol-4-yl)pyridin-3-...) Show SMILES Cn1cc(cn1)-c1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCCN(C4)S(C)(=O)=O)c3c2c1 Show InChI InChI=1S/C26H27N7O3S/c1-30-15-19(13-29-30)22-8-7-18(12-27-22)17-6-9-23-21(11-17)25-24(14-28-23)31(2)26(34)33(25)20-5-4-10-32(16-20)37(3,35)36/h6-9,11-15,20H,4-5,10,16H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
BEIJING FORELANDPHARMA CO. LTD. US Patent					Assay Description The inhibition of the mTOR protein kinase activity by the compounds was determined by the enzymatic activity assay in vitro. The detection kit suppli...				US Patent US10047084 (2018) BindingDB Entry DOI: 10.7270/Q2DZ0B95
					More data for this Ligand-Target Pair
PI3-kinase class I (Homo sapiens (Human))	BDBM228204 (3-methyl-8-(6-(1-methyl-1H-pyrazol-4-yl)pyridin-3-...) Show SMILES Cn1cc(cn1)-c1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCCN(C4)S(C)(=O)=O)c3c2c1 Show InChI InChI=1S/C26H27N7O3S/c1-30-15-19(13-29-30)22-8-7-18(12-27-22)17-6-9-23-21(11-17)25-24(14-28-23)31(2)26(34)33(25)20-5-4-10-32(16-20)37(3,35)36/h6-9,11-15,20H,4-5,10,16H2,1-3H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
BEIJING FORELANDPHARMA CO. LTD. US Patent					Assay Description PI3K alpha-ADP Glo Assay was employed. In the determination of PI3K enzyme activity, the detection kit supplied by Promega (Promega, Cat #: V9101) wa...				US Patent US10047084 (2018) BindingDB Entry DOI: 10.7270/Q2DZ0B95
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM228204 (3-methyl-8-(6-(1-methyl-1H-pyrazol-4-yl)pyridin-3-...) Show SMILES Cn1cc(cn1)-c1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCCN(C4)S(C)(=O)=O)c3c2c1 Show InChI InChI=1S/C26H27N7O3S/c1-30-15-19(13-29-30)22-8-7-18(12-27-22)17-6-9-23-21(11-17)25-24(14-28-23)31(2)26(34)33(25)20-5-4-10-32(16-20)37(3,35)36/h6-9,11-15,20H,4-5,10,16H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
BEIJING FORELANDPHARMA CO. LTD. US Patent					Assay Description The inhibition of the mTOR protein kinase activity by the compounds was determined by the enzymatic activity assay in vitro. The detection kit suppli...				US Patent US10047084 (2018) BindingDB Entry DOI: 10.7270/Q2DZ0B95
					More data for this Ligand-Target Pair