BDBM2286 5Cl3PhS-2IndolCONH2 inhibitor 12::N-methyl-3-(phenylsulfanyl)-1H-indole-2-carboxamide
SMILES: CNC(=O)c1[nH]c2ccccc2c1Sc1ccccc1
InChI Key: InChIKey=QMDHGQMUCLDYCH-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
HIV-1 Reverse Transcriptase (Human immunodeficiency virus type 1) | BDBM2286 (5Cl3PhS-2IndolCONH2 inhibitor 12 | N-methyl-3-(phe...) | PDB MMDB B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 746 | n/a | n/a | n/a | n/a | 8.2 | n/a |
Merck Research Laboratories | Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro. | J Med Chem 36: 1291-4 (1993) Article DOI: 10.1021/jm00061a022 BindingDB Entry DOI: 10.7270/Q2RV0KWR | |||||||||||
More data for this Ligand-Target Pair |