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BDBM22866 2-(1,3-thiazol-2-yl)ethan-1-amine::2-(2-Thiazolyl)ethanamine::2-(2-aminoethyl)thiazole::2-Thiazolylethylamine::TEA

SMILES: NCCc1nccs1

InChI Key: InChIKey=TWZOYAWHWDRMEZ-UHFFFAOYSA-N

Data: 2 KI

PDB links: 28 PDB IDs contain this monomer as substructures. 28 PDB IDs contain inhibitors having a similarity of 90% to this monomer.

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 22866   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM22866
PNG
(2-(1,3-thiazol-2-yl)ethan-1-amine | 2-(2-Thiazolyl...)
Show SMILES NCCc1nccs1
Show InChI InChI=1S/C5H8N2S/c6-2-1-5-7-3-4-8-5/h3-4H,1-2,6H2
UniProtKB/SwissProt

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KEGG
PC cid
PC sid
UniChem

Patents

Article
PubMed
8.49E+3n/an/an/an/an/an/an/an/a



University of Kansas

Curated by PDSP Ki Database




J Pharmacol Exp Ther 305: 1104-15 (2003)

More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM22866
PNG
(2-(1,3-thiazol-2-yl)ethan-1-amine | 2-(2-Thiazolyl...)
Show SMILES NCCc1nccs1
Show InChI InChI=1S/C5H8N2S/c6-2-1-5-7-3-4-8-5/h3-4H,1-2,6H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

KEGG
PC cid
PC sid
UniChem

Patents

Article
PubMed
>1.00E+4>-7.09n/an/an/an/an/a7.437



Vrije Universiteit Amsterdam



Assay Description
Ligand displacement assays were performed on The SK-N-MC/hH4R cell homogenates. Retained radioactivity was determined by liquid scintillation countin...


J Pharmacol Exp Ther 314: 1310-21 (2005)

More data for this
Ligand-Target Pair