BDBM22866 2-(1,3-thiazol-2-yl)ethan-1-amine::2-(2-Thiazolyl)ethanamine::2-(2-aminoethyl)thiazole::2-Thiazolylethylamine::TEA

SMILES: NCCc1nccs1

InChI Key: InChIKey=TWZOYAWHWDRMEZ-UHFFFAOYSA-N

Data: 2 KI  1 EC50

PDB links: 28 PDB IDs contain this monomer as substructures. 28 PDB IDs contain inhibitors having a similarity of 90% to this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 22866   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM22866 (2-(1,3-thiazol-2-yl)ethan-1-amine | 2-(2-Thiazolyl...) Show SMILES NCCc1nccs1 Show InChI InChI=1S/C5H8N2S/c6-2-1-5-7-3-4-8-5/h3-4H,1-2,6H2	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents	Article PubMed	8.49E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kansas Curated by PDSP Ki Database									J Pharmacol Exp Ther 305: 1104-15 (2003) Article DOI: 10.1124/jpet.103.049619 BindingDB Entry DOI: 10.7270/Q2HM5708
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM22866 (2-(1,3-thiazol-2-yl)ethan-1-amine | 2-(2-Thiazolyl...) Show SMILES NCCc1nccs1 Show InChI InChI=1S/C5H8N2S/c6-2-1-5-7-3-4-8-5/h3-4H,1-2,6H2	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents	Article PubMed	>1.00E+4	>-7.09	n/a	n/a	n/a	n/a	n/a	7.4	37
Vrije Universiteit Amsterdam					Assay Description Ligand displacement assays were performed on The SK-N-MC/hH4R cell homogenates. Retained radioactivity was determined by liquid scintillation countin...				J Pharmacol Exp Ther 314: 1310-21 (2005) Article DOI: 10.1124/jpet.105.087965 BindingDB Entry DOI: 10.7270/Q2KD1W6V
					More data for this Ligand-Target Pair
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM22866 (2-(1,3-thiazol-2-yl)ethan-1-amine | 2-(2-Thiazolyl...) Show SMILES NCCc1nccs1 Show InChI InChI=1S/C5H8N2S/c6-2-1-5-7-3-4-8-5/h3-4H,1-2,6H2	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	1.00E+14	n/a	n/a	n/a	n/a
Freie Universit£t Berlin Curated by ChEMBL					Assay Description H1-Histamine receptor agonism on Guinea pig aorta was evaluated (SEM 0.03-0.18)				J Med Chem 38: 1287-94 (1995) Article DOI: 10.1021/jm00008a007 BindingDB Entry DOI: 10.7270/Q2CV4MGW
					More data for this Ligand-Target Pair