BDBM228660 (-)-2-(2-(1H-Benzo[d]imidazol-1-yl)-N-(3-fluorophenyl)acetamido)-N-cyclopentyl-2-o-tolylacetamide::(-)-ML309
SMILES: Cc1ccccc1[C@H](N(C(=O)Cn1cnc2ccccc12)c1cccc(F)c1)C(=O)NC1CCCC1
InChI Key: InChIKey=GZLNOSRHZLTDMT-NDEPHWFRSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Isocitrate dehydrogenase [NADP] cytoplasmic [R132C] (Homo sapiens (Human)) | BDBM228660 ((-)-2-(2-(1H-Benzo[d]imidazol-1-yl)-N-(3-fluorophe...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institutes of Health | Assay Description The activity of IDH1 R132H and IDH1 R132C was measured in 384-well plates by coupling NADPH consumption to a diaphorase/resazurin-based detection sys... | J Biol Chem 289: 13717-25 (2014) Article DOI: 10.1074/jbc.M113.511030 BindingDB Entry DOI: 10.7270/Q2513X35 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isocitrate dehydrogenase [NADP] cytoplasmic [R132H] (Homo sapiens (Human)) | BDBM228660 ((-)-2-(2-(1H-Benzo[d]imidazol-1-yl)-N-(3-fluorophe...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institutes of Health | Assay Description The activity of IDH1 R132H and IDH1 R132C was measured in 384-well plates by coupling NADPH consumption to a diaphorase/resazurin-based detection sys... | J Biol Chem 289: 13717-25 (2014) Article DOI: 10.1074/jbc.M113.511030 BindingDB Entry DOI: 10.7270/Q2513X35 | |||||||||||
More data for this Ligand-Target Pair |