BindingDB PrimarySearch

BDBM22872 1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-yl)-4-methyl-piperazine;maleate::1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl)-4-methylpiperazine::1-{6-chloro-2-thiatricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3(8),4,6,11,13-hexaen-9-yl}-4-methylpiperazine::CHEMBL64249::CLOROTEPINE (+)::CLOROTEPINE(-)::Clothepin::OCTOCLOTHEPIN,(+)::OCTOCLOTHEPIN,(-)::Octoclothepin::Octoclothepine

SMILES: CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(Cl)cc12

InChI Key: InChIKey=XRYLGRGAWQSVQW-UHFFFAOYSA-N

Data: 27 KI 8 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 35 hits for monomerid = 22872
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Histamine H1 receptor (Homo sapiens (Human))	BDBM22872 (1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-y...) Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(Cl)cc12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.190	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Displacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cells				J Med Chem 53: 7021-34 (2010) Article DOI: 10.1021/jm100652h BindingDB Entry DOI: 10.7270/Q20C4W0P
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM22872 (1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-y...) Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(Cl)cc12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
ACADIA Pharmaceuticals Curated by PDSP K_i Database									J Pharmacol Exp Ther 315: 1278-87 (2005) Article DOI: 10.1124/jpet.105.092155 BindingDB Entry DOI: 10.7270/Q2Z60MNB
ACADIA Pharmaceuticals Curated by PDSP K_i Database					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM22872 (1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-y...) Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(Cl)cc12 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
ACADIA Pharmaceuticals Curated by PDSP K_i Database									J Pharmacol Exp Ther 315: 1278-87 (2005) Article DOI: 10.1124/jpet.105.092155 BindingDB Entry DOI: 10.7270/Q2Z60MNB
ACADIA Pharmaceuticals Curated by PDSP K_i Database					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM22872 (1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-y...) Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(Cl)cc12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	0.230	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Siena Curated by ChEMBL					Assay Description Half-maximal inhibition of [3H]ketanserin binding to 5-hydroxytryptamine 2A receptor in rat cerebral cortex homogenate				J Med Chem 45: 344-59 (2002) BindingDB Entry DOI: 10.7270/Q2TX3G26
Universit£ degli Studi di Siena Curated by ChEMBL					More data for this Ligand-Target Pair
Serotonin (5-HT) receptor (Rattus norvegicus (rat))	BDBM22872 (1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-y...) Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(Cl)cc12 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	0.380	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by PDSP K_i Database									J Pharmacol Exp Ther 268: 1403-10 (1994) BindingDB Entry DOI: 10.7270/Q2154FJQ
					More data for this Ligand-Target Pair
D(4) dopamine receptor (Homo sapiens (Human))	BDBM22872 (1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-y...) Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(Cl)cc12 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
ACADIA Pharmaceuticals Curated by PDSP K_i Database									J Pharmacol Exp Ther 315: 1278-87 (2005) Article DOI: 10.1124/jpet.105.092155 BindingDB Entry DOI: 10.7270/Q2Z60MNB
ACADIA Pharmaceuticals Curated by PDSP K_i Database					More data for this Ligand-Target Pair
HTR6 (RAT)	BDBM22872 (1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-y...) Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(Cl)cc12 Show InChI	Reactome pathway UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	0.410	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by PDSP K_i Database									J Pharmacol Exp Ther 268: 1403-10 (1994) BindingDB Entry DOI: 10.7270/Q2154FJQ
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM22872 (1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-y...) Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(Cl)cc12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	0.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Siena Curated by ChEMBL					Assay Description Half-maximal inhibition of [3H]spiperone binding to Dopamine receptor D2 in rat striatal homogenate				J Med Chem 45: 344-59 (2002) BindingDB Entry DOI: 10.7270/Q2TX3G26
Universit£ degli Studi di Siena Curated by ChEMBL					More data for this Ligand-Target Pair
ADRA1B (C.H.O.)	BDBM22872 (1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-y...) Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(Cl)cc12 Show InChI	Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.560	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Displacement of [3H]prozosin from hamster cloned alpha1b receptor				J Med Chem 53: 7021-34 (2010) Article DOI: 10.1021/jm100652h BindingDB Entry DOI: 10.7270/Q20C4W0P
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM22872 (1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-y...) Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(Cl)cc12 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.570	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Displacement of [3H]prozosin from human cloned 5HT2C receptor expressed in CHO cells				J Med Chem 53: 7021-34 (2010) Article DOI: 10.1021/jm100652h BindingDB Entry DOI: 10.7270/Q20C4W0P
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
Cerebral cortex alpha adrenergic receptor (CALF)	BDBM22872 (1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-y...) Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(Cl)cc12 Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.660	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Displacement of [3H]prozosin from bovine cloned alpha1a receptor expressed in BHK cells				J Med Chem 53: 7021-34 (2010) Article DOI: 10.1021/jm100652h BindingDB Entry DOI: 10.7270/Q20C4W0P
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM22872 (1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-y...) Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(Cl)cc12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.670	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Displacement of [3H]prozosin from human cloned dopamine D2 receptor expressed in CHO cells				J Med Chem 53: 7021-34 (2010) Article DOI: 10.1021/jm100652h BindingDB Entry DOI: 10.7270/Q20C4W0P
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM22872 (1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-y...) Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(Cl)cc12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.700	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
ACADIA Pharmaceuticals Curated by PDSP K_i Database									J Pharmacol Exp Ther 315: 1278-87 (2005) Article DOI: 10.1124/jpet.105.092155 BindingDB Entry DOI: 10.7270/Q2Z60MNB
ACADIA Pharmaceuticals Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Alpha-1D adrenergic receptor (Rattus norvegicus (Rat))	BDBM22872 (1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-y...) Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(Cl)cc12 Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.770	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Displacement of [3H]prozosin from rat cloned alpha1d receptor				J Med Chem 53: 7021-34 (2010) Article DOI: 10.1021/jm100652h BindingDB Entry DOI: 10.7270/Q20C4W0P
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM22872 (1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-y...) Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(Cl)cc12 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
ACADIA Pharmaceuticals Curated by PDSP K_i Database									J Pharmacol Exp Ther 315: 1278-87 (2005) Article DOI: 10.1124/jpet.105.092155 BindingDB Entry DOI: 10.7270/Q2Z60MNB
ACADIA Pharmaceuticals Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Serotonin (5-HT) receptor (Rattus norvegicus (rat))	BDBM22872 (1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-y...) Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(Cl)cc12 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	1.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by PDSP K_i Database									J Pharmacol Exp Ther 268: 1403-10 (1994) BindingDB Entry DOI: 10.7270/Q2154FJQ
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM22872 (1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-y...) Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(Cl)cc12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	1.58	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by PDSP K_i Database									J Pharmacol Exp Ther 268: 1403-10 (1994) BindingDB Entry DOI: 10.7270/Q2154FJQ
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM22872 (1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-y...) Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(Cl)cc12 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Washington Curated by PDSP K_i Database									J Neurochem 66: 47-56 (1996) Article DOI: 10.1046/j.1471-4159.1996.66010047.x BindingDB Entry DOI: 10.7270/Q20K2721
University of Washington Curated by PDSP K_i Database					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM22872 (1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-y...) Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(Cl)cc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	2.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Siena Curated by ChEMBL					Assay Description Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate				J Med Chem 45: 344-59 (2002) BindingDB Entry DOI: 10.7270/Q2TX3G26
Universit£ degli Studi di Siena Curated by ChEMBL					More data for this Ligand-Target Pair
D(3) dopamine receptor (Rattus norvegicus (Rat))	BDBM22872 (1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-y...) Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(Cl)cc12 Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	2.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Siena Curated by ChEMBL					Assay Description Half-maximal inhibition of [3H]-7-OH-DPAT binding to Dopamine receptor D3 in rat tissue homogenate				J Med Chem 45: 344-59 (2002) BindingDB Entry DOI: 10.7270/Q2TX3G26
Universit£ degli Studi di Siena Curated by ChEMBL					More data for this Ligand-Target Pair
HTR7 (GUINEA PIG)	BDBM22872 (1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-y...) Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(Cl)cc12 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.51	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Discovery Research Curated by PDSP K_i Database									Br J Pharmacol 115: 107-16 (1995) Article DOI: 10.1111/j.1476-5381.1995.tb16327.x BindingDB Entry DOI: 10.7270/Q2610XTR
Syntex Discovery Research Curated by PDSP K_i Database					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM22872 (1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-y...) Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(Cl)cc12 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Washington Curated by PDSP K_i Database									J Neurochem 66: 47-56 (1996) Article DOI: 10.1046/j.1471-4159.1996.66010047.x BindingDB Entry DOI: 10.7270/Q20K2721
University of Washington Curated by PDSP K_i Database					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM22872 (1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-y...) Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(Cl)cc12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	12.6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by PDSP K_i Database									J Pharmacol Exp Ther 268: 1403-10 (1994) BindingDB Entry DOI: 10.7270/Q2154FJQ
					More data for this Ligand-Target Pair
HTR6 (RAT)	BDBM22872 (1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-y...) Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(Cl)cc12 Show InChI	Reactome pathway UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	17.7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by PDSP K_i Database									J Pharmacol Exp Ther 268: 1403-10 (1994) BindingDB Entry DOI: 10.7270/Q2154FJQ
					More data for this Ligand-Target Pair
HTR7 (GUINEA PIG)	BDBM22872 (1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-y...) Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(Cl)cc12 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	32.4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Discovery Research Curated by PDSP K_i Database									Br J Pharmacol 115: 107-16 (1995) Article DOI: 10.1111/j.1476-5381.1995.tb16327.x BindingDB Entry DOI: 10.7270/Q2610XTR
Syntex Discovery Research Curated by PDSP K_i Database					More data for this Ligand-Target Pair
TRAR1 (Homo sapiens (Human))	BDBM22872 (1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-y...) Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(Cl)cc12 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	493	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Synaptic Pharmaceutical Corporation Curated by PDSP K_i Database									Proc Natl Acad Sci U S A 98: 8966-71 (2001) Article DOI: 10.1073/pnas.151105198 BindingDB Entry DOI: 10.7270/Q2G15ZD5
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM22872 (1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-y...) Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(Cl)cc12 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	>-7.09	n/a	n/a	n/a	n/a	n/a	7.4	37
Vrije Universiteit Amsterdam					Assay Description Ligand displacement assays were performed on The SK-N-MC/hH4R cell homogenates. Retained radioactivity was determined by liquid scintillation countin...				J Pharmacol Exp Ther 314: 1310-21 (2005) Article DOI: 10.1124/jpet.105.087965 BindingDB Entry DOI: 10.7270/Q2KD1W6V
Vrije Universiteit Amsterdam					More data for this Ligand-Target Pair
Potassium channel subfamily K member 9 (Homo sapiens (Human))	BDBM22872 (1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-y...) Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(Cl)cc12 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.38E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universidad de Talca Curated by ChEMBL					Assay Description Inhibition of human TASK3 expressed in HEK293 cells by Ti+ flux assay				J Med Chem 62: 10044-10058 (2019) Article DOI: 10.1021/acs.jmedchem.9b00248
Universidad de Talca Curated by ChEMBL					More data for this Ligand-Target Pair
Dopamine receptor (Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)	BDBM22872 (1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-y...) Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(Cl)cc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Ability to displace [3H]haloperidol from rat striatal membranes, in order to measure its intrinsic affinity for the dopamine (DA) receptor				J Med Chem 26: 935-47 (1983) BindingDB Entry DOI: 10.7270/Q2JH3MR6
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM22872 (1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-y...) Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(Cl)cc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Ability to inhibit binding of [3H]-SCH- 23390 to Dopamine receptor D1 in rat striatal membranes				J Med Chem 34: 2023-30 (1991) BindingDB Entry DOI: 10.7270/Q2KD1WVC
H. Lundbeck A/S Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM22872 (1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-y...) Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(Cl)cc12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Ability to inhibit binding of [3H]-SPI to dopamine receptor D2 in rat striatal membranes				J Med Chem 34: 2023-30 (1991) BindingDB Entry DOI: 10.7270/Q2KD1WVC
H. Lundbeck A/S Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM22872 (1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-y...) Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(Cl)cc12 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.180	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Ability to inhibit binding of [3H]PRAZ to alpha-1 adrenergic receptor in rat brain				J Med Chem 34: 2023-30 (1991) BindingDB Entry DOI: 10.7270/Q2KD1WVC
H. Lundbeck A/S Curated by ChEMBL					More data for this Ligand-Target Pair
Serotonin 2 (5-HT2) receptor (Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)	BDBM22872 (1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-y...) Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(Cl)cc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.570	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Ability to inhibit binding of [3H]KET to 5-hydroxytryptamine 2 receptor in rat cortex				J Med Chem 34: 2023-30 (1991) BindingDB Entry DOI: 10.7270/Q2KD1WVC
H. Lundbeck A/S Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium channel subfamily K member 9 (Homo sapiens (Human))	BDBM22872 (1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-y...) Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(Cl)cc12 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.38E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universidad de Talca Curated by ChEMBL					Assay Description Inhibition of human TASK3 expressed in HEK293 cells by Ti+ flux assay				J Med Chem 62: 10044-10058 (2019) Article DOI: 10.1021/acs.jmedchem.9b00248
Universidad de Talca Curated by ChEMBL					More data for this Ligand-Target Pair
ubiquitin-conjugating enzyme E2 N (Homo sapiens (Human))	BDBM22872 (1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-y...) Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(Cl)cc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Burnham Center for Chemical Genomics Curated by PubChem BioAssay					Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA...				PubChem Bioassay (2011) BindingDB Entry DOI: 10.7270/Q2X34VX0
					More data for this Ligand-Target Pair