BDBM22881 5-(2-aminoethyl)-4-methyl-1,3-thiazol-2-amine::Amthamine::CHEMBL554964
SMILES: Cc1nc(N)sc1CCN
InChI Key: InChIKey=LHVRFUVVRXGZPV-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Histamine H4 receptor (Homo sapiens (Human)) | BDBM22881 (5-(2-aminoethyl)-4-methyl-1,3-thiazol-2-amine | Am...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 5.01E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Regensburg Curated by ChEMBL | Assay Description Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 | Bioorg Med Chem Lett 20: 7191-9 (2010) Article DOI: 10.1016/j.bmcl.2010.10.041 BindingDB Entry DOI: 10.7270/Q2Q81GX5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H4 receptor (Homo sapiens (Human)) | BDBM22881 (5-(2-aminoethyl)-4-methyl-1,3-thiazol-2-amine | Am...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 5.01E+3 | -7.52 | n/a | n/a | n/a | n/a | n/a | 7.4 | 37 |
Vrije Universiteit Amsterdam | Assay Description Ligand displacement assays were performed on The SK-N-MC/hH4R cell homogenates. Retained radioactivity was determined by liquid scintillation countin... | J Pharmacol Exp Ther 314: 1310-21 (2005) Article DOI: 10.1124/jpet.105.087965 BindingDB Entry DOI: 10.7270/Q2KD1W6V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H2 receptor (Homo sapiens (Human)) | BDBM22881 (5-(2-aminoethyl)-4-methyl-1,3-thiazol-2-amine | Am...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 6.31E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Regensburg Curated by ChEMBL | Assay Description Displacement of [125I]iodoaminopotentidine from human histamine H2 receptor expressed in CHO cells | Bioorg Med Chem Lett 20: 7191-9 (2010) Article DOI: 10.1016/j.bmcl.2010.10.041 BindingDB Entry DOI: 10.7270/Q2Q81GX5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H2 receptor (RAT) | BDBM22881 (5-(2-aminoethyl)-4-methyl-1,3-thiazol-2-amine | Am...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | n/a | 1.15E+4 | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Affinity to the Histamine H2 receptor was determined expressed in CHO cell using [125I]iodoaminopotentidine as radioligand | Bioorg Med Chem Lett 4: 1913-1916 (1994) Article DOI: 10.1016/S0960-894X(01)80533-3 BindingDB Entry DOI: 10.7270/Q2TD9ZHX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H1 receptor (Homo sapiens (Human)) | BDBM22881 (5-(2-aminoethyl)-4-methyl-1,3-thiazol-2-amine | Am...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.58E+4 | n/a | n/a | n/a | n/a |
University of Regensburg Curated by ChEMBL | Assay Description Agonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assay | Bioorg Med Chem Lett 20: 7191-9 (2010) Article DOI: 10.1016/j.bmcl.2010.10.041 BindingDB Entry DOI: 10.7270/Q2Q81GX5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H2 receptor (Homo sapiens (Human)) | BDBM22881 (5-(2-aminoethyl)-4-methyl-1,3-thiazol-2-amine | Am...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 191 | n/a | n/a | n/a | n/a |
University of Regensburg Curated by ChEMBL | Assay Description Agonist activity at human H2R-Gsalphas expressed in Sf9 cells at 0.1 nM to 10 uM by steady state GTPase activity assay | J Med Chem 55: 1147-60 (2012) Article DOI: 10.1021/jm201128q BindingDB Entry DOI: 10.7270/Q2HQ411W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H2 receptor (Cavia porcellus (domestic guinea pig)) | BDBM22881 (5-(2-aminoethyl)-4-methyl-1,3-thiazol-2-amine | Am...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 191 | n/a | n/a | n/a | n/a |
University of Regensburg Curated by ChEMBL | Assay Description Agonist activity at guinea pig H2R-Gsalphas expressed in Sf9 cells at 0.1 nM to 10 uM by steady state GTPase activity assay | J Med Chem 55: 1147-60 (2012) Article DOI: 10.1021/jm201128q BindingDB Entry DOI: 10.7270/Q2HQ411W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H2 receptor (Cavia porcellus (domestic guinea pig)) | BDBM22881 (5-(2-aminoethyl)-4-methyl-1,3-thiazol-2-amine | Am...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 617 | n/a | n/a | n/a | n/a |
University of Regensburg Curated by ChEMBL | Assay Description Agonist activity at H2R in spontaneously beating guinea pig right atrium assessed as increase in heart rate | J Med Chem 55: 1147-60 (2012) Article DOI: 10.1021/jm201128q BindingDB Entry DOI: 10.7270/Q2HQ411W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H2 receptor (Cavia porcellus (domestic guinea pig)) | BDBM22881 (5-(2-aminoethyl)-4-methyl-1,3-thiazol-2-amine | Am...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | 5.01E+3 | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit Curated by ChEMBL | Assay Description Compound is evaluated for histamine H2 receptor agonistic activity in guinea pig cerebral cortex using [3H]tiotidine as radioligand | J Med Chem 35: 3239-46 (1992) BindingDB Entry DOI: 10.7270/Q2C53N4J | |||||||||||
More data for this Ligand-Target Pair |