Found 13 hits for monomerid = 22883 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM22883
(CHEMBL12344 | Dimaprit | [3-(carbamimidoylsulfanyl...)Show InChI InChI=1S/C6H15N3S/c1-9(2)4-3-5-10-6(7)8/h3-5H2,1-2H3,(H3,7,8) | Reactome pathway KEGG
UniProtKB/SwissProt
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Patents
| Article PubMed
| 90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc
Curated by ChEMBL
| Assay Description Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells |
J Med Chem 51: 3145-53 (2008)
Article DOI: 10.1021/jm7014777 BindingDB Entry DOI: 10.7270/Q2M046BP |
More data for this Ligand-Target Pair | |
Histamine receptor (H3 and H4)
(Homo sapiens (Human)) | BDBM22883
(CHEMBL12344 | Dimaprit | [3-(carbamimidoylsulfanyl...)Show InChI InChI=1S/C6H15N3S/c1-9(2)4-3-5-10-6(7)8/h3-5H2,1-2H3,(H3,7,8) | Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL MCE KEGG PC cid PC sid UniChem
Patents
| Article PubMed
| 316 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit Amsterdam
Curated by ChEMBL
| Assay Description Displacement of [3H]histamine from human histamine H4 receptor |
J Med Chem 49: 6650-1 (2006)
Article DOI: 10.1021/jm060880d BindingDB Entry DOI: 10.7270/Q25H7K1G |
More data for this Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM22883
(CHEMBL12344 | Dimaprit | [3-(carbamimidoylsulfanyl...)Show InChI InChI=1S/C6H15N3S/c1-9(2)4-3-5-10-6(7)8/h3-5H2,1-2H3,(H3,7,8) | Reactome pathway KEGG
UniProtKB/SwissProt
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Patents
| Article PubMed
| 316 | -9.22 | n/a | n/a | n/a | n/a | n/a | 7.4 | 37 |
Vrije Universiteit Amsterdam
| Assay Description Ligand displacement assays were performed on The SK-N-MC/hH4R cell homogenates. Retained radioactivity was determined by liquid scintillation countin... |
J Pharmacol Exp Ther 314: 1310-21 (2005)
Article DOI: 10.1124/jpet.105.087965 BindingDB Entry DOI: 10.7270/Q2KD1W6V |
More data for this Ligand-Target Pair | |
Histamine receptor (H3 and H4)
(Homo sapiens (Human)) | BDBM22883
(CHEMBL12344 | Dimaprit | [3-(carbamimidoylsulfanyl...)Show InChI InChI=1S/C6H15N3S/c1-9(2)4-3-5-10-6(7)8/h3-5H2,1-2H3,(H3,7,8) | Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL MCE KEGG PC cid PC sid UniChem
Patents
| Article PubMed
| 316 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Regensburg
Curated by ChEMBL
| Assay Description Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 |
Bioorg Med Chem Lett 20: 7191-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.041 BindingDB Entry DOI: 10.7270/Q2Q81GX5 |
More data for this Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM22883
(CHEMBL12344 | Dimaprit | [3-(carbamimidoylsulfanyl...)Show InChI InChI=1S/C6H15N3S/c1-9(2)4-3-5-10-6(7)8/h3-5H2,1-2H3,(H3,7,8) | Reactome pathway KEGG
UniProtKB/SwissProt
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Patents
| Article PubMed
| 377 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
| |
Mol Pharmacol 59: 420-6 (2001)
Article DOI: 10.1124/mol.59.3.420 BindingDB Entry DOI: 10.7270/Q26Q1VSR |
More data for this Ligand-Target Pair | |
HRH3
(RAT) | BDBM22883
(CHEMBL12344 | Dimaprit | [3-(carbamimidoylsulfanyl...)Show InChI InChI=1S/C6H15N3S/c1-9(2)4-3-5-10-6(7)8/h3-5H2,1-2H3,(H3,7,8) | KEGG
UniProtKB/TrEMBL
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Patents
| Article PubMed
| 440 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research
Curated by PDSP Ki Database
| |
J Neurochem 55: 1612-6 (1990)
Article DOI: 10.1111/j.1471-4159.1990.tb04946.x BindingDB Entry DOI: 10.7270/Q2X63KF2 |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM22883
(CHEMBL12344 | Dimaprit | [3-(carbamimidoylsulfanyl...)Show InChI InChI=1S/C6H15N3S/c1-9(2)4-3-5-10-6(7)8/h3-5H2,1-2H3,(H3,7,8) | Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL MCE KEGG PC cid PC sid UniChem
Patents
| Article PubMed
| 825 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
| |
Mol Pharmacol 59: 420-6 (2001)
Article DOI: 10.1124/mol.59.3.420 BindingDB Entry DOI: 10.7270/Q26Q1VSR |
More data for this Ligand-Target Pair | |
Histamine H1 receptor
(RAT) | BDBM22883
(CHEMBL12344 | Dimaprit | [3-(carbamimidoylsulfanyl...)Show InChI InChI=1S/C6H15N3S/c1-9(2)4-3-5-10-6(7)8/h3-5H2,1-2H3,(H3,7,8) | KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
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CHEMBL MCE KEGG PC cid PC sid UniChem
Patents
| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by PDSP Ki Database
| |
Proc Natl Acad Sci U S A 75: 6290-4 (1978)
Article DOI: 10.1073/pnas.75.12.6290 BindingDB Entry DOI: 10.7270/Q2FN14P6 |
More data for this Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM22883
(CHEMBL12344 | Dimaprit | [3-(carbamimidoylsulfanyl...)Show InChI InChI=1S/C6H15N3S/c1-9(2)4-3-5-10-6(7)8/h3-5H2,1-2H3,(H3,7,8) | UniProtKB/SwissProt
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CHEMBL MCE KEGG PC cid PC sid UniChem
Patents
| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hoechst Pharmaceutical Research Laboratories
Curated by PDSP Ki Database
| |
Nature 304: 65-7 (1983)
Article DOI: 10.1038/304065a0 BindingDB Entry DOI: 10.7270/Q2930RN2 |
More data for this Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM22883
(CHEMBL12344 | Dimaprit | [3-(carbamimidoylsulfanyl...)Show InChI InChI=1S/C6H15N3S/c1-9(2)4-3-5-10-6(7)8/h3-5H2,1-2H3,(H3,7,8) | Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL MCE KEGG PC cid PC sid UniChem
Patents
| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Centre for Addiction and Mental Health
Curated by PDSP Ki Database
| |
Mol Pharmacol 59: 427-33 (2001)
Article DOI: 10.1124/mol.59.3.427 BindingDB Entry DOI: 10.7270/Q22Z1438 |
More data for this Ligand-Target Pair | |
Histamine H2 receptor
(Homo sapiens (Human)) | BDBM22883
(CHEMBL12344 | Dimaprit | [3-(carbamimidoylsulfanyl...)Show InChI InChI=1S/C6H15N3S/c1-9(2)4-3-5-10-6(7)8/h3-5H2,1-2H3,(H3,7,8) | Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL MCE KEGG PC cid PC sid UniChem
Patents
| Article PubMed
| 2.51E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Regensburg
Curated by ChEMBL
| Assay Description Displacement of [125I]iodoaminopotentidine from human histamine H2 receptor expressed in CHO cells |
Bioorg Med Chem Lett 20: 7191-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.041 BindingDB Entry DOI: 10.7270/Q2Q81GX5 |
More data for this Ligand-Target Pair | |
Histamine receptor (H3 and H4)
(Homo sapiens (Human)) | BDBM22883
(CHEMBL12344 | Dimaprit | [3-(carbamimidoylsulfanyl...)Show InChI InChI=1S/C6H15N3S/c1-9(2)4-3-5-10-6(7)8/h3-5H2,1-2H3,(H3,7,8) | Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL MCE KEGG PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | n/a | n/a | 1.59E+3 | n/a | n/a | n/a | n/a |
University of Regensburg
Curated by ChEMBL
| Assay Description Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay |
Bioorg Med Chem Lett 20: 7191-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.041 BindingDB Entry DOI: 10.7270/Q2Q81GX5 |
More data for this Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM22883
(CHEMBL12344 | Dimaprit | [3-(carbamimidoylsulfanyl...)Show InChI InChI=1S/C6H15N3S/c1-9(2)4-3-5-10-6(7)8/h3-5H2,1-2H3,(H3,7,8) | UniProtKB/SwissProt
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Patents
| PubMed
| n/a | n/a | n/a | 2.63E+4 | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit
Curated by ChEMBL
| Assay Description Compound is evaluated for histamine H2 receptor agonistic activity in guinea pig cerebral cortex using [3H]tiotidine as radioligand |
J Med Chem 35: 3239-46 (1992)
BindingDB Entry DOI: 10.7270/Q2C53N4J |
More data for this Ligand-Target Pair | |