BDBM22892 DA 4577::DA-4577::Mifentidine::N-[4-(1H-imidazol-5-yl)phenyl]-N'-propan-2-ylmethanimidamide

SMILES: CC(C)NC=Nc1ccc(cc1)-c1c[nH]cn1

InChI Key: InChIKey=GOZUADYOHPCXLE-UHFFFAOYSA-N

Data: 1 KI  3 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 22892   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H4 receptor (Homo sapiens (Human))	BDBM22892 (DA 4577 | DA-4577 | Mifentidine | N-[4-(1H-imidazo...) Show SMILES CC(C)NC=Nc1ccc(cc1)-c1c[nH]cn1 |w:5.5| Show InChI InChI=1S/C13H16N4/c1-10(2)15-9-16-12-5-3-11(4-6-12)13-7-14-8-17-13/h3-10H,1-2H3,(H,14,17)(H,15,16)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vrije Universiteit Amsterdam					Assay Description Ligand displacement assays were performed on The SK-N-MC/hH4R cell homogenates. Retained radioactivity was determined by liquid scintillation countin...				J Pharmacol Exp Ther 314: 1310-21 (2005) Article DOI: 10.1124/jpet.105.087965 BindingDB Entry DOI: 10.7270/Q2KD1W6V
					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM22892 (DA 4577 | DA-4577 | Mifentidine | N-[4-(1H-imidazo...) Show SMILES CC(C)NC=Nc1ccc(cc1)-c1c[nH]cn1 |w:5.5| Show InChI InChI=1S/C13H16N4/c1-10(2)15-9-16-12-5-3-11(4-6-12)13-7-14-8-17-13/h3-10H,1-2H3,(H,14,17)(H,15,16)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	17	n/a	n/a	n/a	7.4	n/a
TBA Curated by ChEMBL					Assay Description Antagonistic activity of guinea pig Histamine H2 receptor expressed as pA2 at pH 7.4				J Med Chem 30: 208-11 (1987) BindingDB Entry DOI: 10.7270/Q2ZC842P
					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM22892 (DA 4577 | DA-4577 | Mifentidine | N-[4-(1H-imidazo...) Show SMILES CC(C)NC=Nc1ccc(cc1)-c1c[nH]cn1 |w:5.5| Show InChI InChI=1S/C13H16N4/c1-10(2)15-9-16-12-5-3-11(4-6-12)13-7-14-8-17-13/h3-10H,1-2H3,(H,14,17)(H,15,16)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	45.7	n/a	n/a	n/a	7.0	n/a
TBA Curated by ChEMBL					Assay Description Antagonistic activity of guinea pig Histamine H2 receptor expressed as pA2 at pH 7.0				J Med Chem 30: 208-11 (1987) BindingDB Entry DOI: 10.7270/Q2ZC842P
					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM22892 (DA 4577 | DA-4577 | Mifentidine | N-[4-(1H-imidazo...) Show SMILES CC(C)NC=Nc1ccc(cc1)-c1c[nH]cn1 |w:5.5| Show InChI InChI=1S/C13H16N4/c1-10(2)15-9-16-12-5-3-11(4-6-12)13-7-14-8-17-13/h3-10H,1-2H3,(H,14,17)(H,15,16)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	12	n/a	n/a	n/a	7.8	n/a
TBA Curated by ChEMBL					Assay Description Antagonistic activity of guinea pig Histamine H2 receptor expressed as pA2 at pH 7.8				J Med Chem 30: 208-11 (1987) BindingDB Entry DOI: 10.7270/Q2ZC842P
					More data for this Ligand-Target Pair