BDBM23066 7-(4-methanesulfonylphenyl)-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]heptan-1-one::alpha-ketooxazole, 5mm
SMILES: CS(=O)(=O)c1ccc(CCCCCCC(=O)c2ncc(o2)-c2ccccn2)cc1
InChI Key: InChIKey=PMVVOJDCVSDECR-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Fatty Acid Amide Hydrolase (Homo sapiens (Human)) | BDBM23066 (7-(4-methanesulfonylphenyl)-1-[5-(pyridin-2-yl)-1,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | 19 | -10.5 | 50 | n/a | n/a | n/a | n/a | n/a | 25 |
The Scripps Research Institute | Assay Description The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe... | J Med Chem 50: 3359-68 (2007) Article DOI: 10.1021/jm061414r BindingDB Entry DOI: 10.7270/Q2DR2SSH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Triacylglycerol Hydrolase (Homo sapiens (Human)) | BDBM23066 (7-(4-methanesulfonylphenyl)-1-[5-(pyridin-2-yl)-1,...) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
The Scripps Research Institute | Assay Description Inhibition of TGH activity was assayed using COS-7 expressed TGH and the chromogenic substrate. IC50 values were determined from the inhibition obser... | J Med Chem 50: 3359-68 (2007) Article DOI: 10.1021/jm061414r BindingDB Entry DOI: 10.7270/Q2DR2SSH | |||||||||||
More data for this Ligand-Target Pair |