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BDBM23067 7-(4-hexylphenyl)-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]heptan-1-one::alpha-ketooxazole, 5nn

SMILES: CCCCCCc1ccc(CCCCCCC(=O)c2ncc(o2)-c2ccccn2)cc1

InChI Key: InChIKey=KNXFTSUMHKYJME-UHFFFAOYSA-N

Data: 1 KI  2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 23067   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fatty Acid Amide Hydrolase


(Homo sapiens (Human))
BDBM23067
PNG
(7-(4-hexylphenyl)-1-[5-(pyridin-2-yl)-1,3-oxazol-2...)
Show SMILES CCCCCCc1ccc(CCCCCCC(=O)c2ncc(o2)-c2ccccn2)cc1
Show InChI InChI=1S/C27H34N2O2/c1-2-3-4-7-12-22-16-18-23(19-17-22)13-8-5-6-9-15-25(30)27-29-21-26(31-27)24-14-10-11-20-28-24/h10-11,14,16-21H,2-9,12-13,15H2,1H3
PDB
MMDB

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KEGG

UniProtKB/SwissProt

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DrugBank
antibodypedia
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PC cid
PC sid
UniChem

Patents

Article
PubMed
6.70 -11.1 30n/an/an/an/an/a25



The Scripps Research Institute



Assay Description
The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...


J Med Chem 50: 3359-68 (2007)


Article DOI: 10.1021/jm061414r
BindingDB Entry DOI: 10.7270/Q2DR2SSH
More data for this
Ligand-Target Pair
Triacylglycerol Hydrolase


(Homo sapiens (Human))
BDBM23067
PNG
(7-(4-hexylphenyl)-1-[5-(pyridin-2-yl)-1,3-oxazol-2...)
Show SMILES CCCCCCc1ccc(CCCCCCC(=O)c2ncc(o2)-c2ccccn2)cc1
Show InChI InChI=1S/C27H34N2O2/c1-2-3-4-7-12-22-16-18-23(19-17-22)13-8-5-6-9-15-25(30)27-29-21-26(31-27)24-14-10-11-20-28-24/h10-11,14,16-21H,2-9,12-13,15H2,1H3
KEGG

UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 3.00E+4n/an/an/an/an/a25



The Scripps Research Institute



Assay Description
Inhibition of TGH activity was assayed using COS-7 expressed TGH and the chromogenic substrate. IC50 values were determined from the inhibition obser...


J Med Chem 50: 3359-68 (2007)


Article DOI: 10.1021/jm061414r
BindingDB Entry DOI: 10.7270/Q2DR2SSH
More data for this
Ligand-Target Pair