null
SMILES: O[C@H]1CN(C[C@@H]1O)c1ncc(cc1-c1ccc([nH]1)C#N)C(=O)Nc1ccc(OC(F)(F)F)cc1
InChI Key:
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase ABL1 [64-515] (Homo sapiens (Human)) | BDBM230777 (US9340537, 31 | US9896444, Example 31) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <0.100 | n/a | n/a | n/a | n/a | 7.5 | 25 |
NOVATIS AG US Patent | Assay Description The assay was performed by mixing 10 μL of the compound pre-diluted with 10 μL of ATP (20 μM ATP with 0.1 μCi [γ-33P]-ATP) with the... | US Patent US9340537 (2016) BindingDB Entry DOI: 10.7270/Q2FB51T5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [64-515] (Homo sapiens (Human)) | BDBM230777 (US9340537, 31 | US9896444, Example 31) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <0.130 | n/a | n/a | n/a | n/a | n/a | n/a |
IRBM-MRL | Assay Description Caliper ABL1 (64-515) Assay: The assay plates were prepared by addition of 50 nL per well of compound solution in 90% DMSO. The kinase reactions were... | J Med Chem 50: 4953-75 (2007) BindingDB Entry DOI: 10.7270/Q2B27XKV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [64-515] (Homo sapiens (Human)) | BDBM230777 (US9340537, 31 | US9896444, Example 31) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
IRBM-MRL | Assay Description Radio ABL1 (64-515) Assay: For determination of ABL kinase activity, the radiometric filter-binding assay was used. The assay was performed by mixing... | J Med Chem 50: 4953-75 (2007) BindingDB Entry DOI: 10.7270/Q2B27XKV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [64-515] (Homo sapiens (Human)) | BDBM230777 (US9340537, 31 | US9896444, Example 31) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <0.130 | n/a | n/a | n/a | n/a | 7.5 | 30 |
NOVATIS AG US Patent | Assay Description The assay plates were prepared by addition of 50 nL per well of compound solution in 90% DMSO. The kinase reactions were started by stepwise addition... | US Patent US9340537 (2016) BindingDB Entry DOI: 10.7270/Q2FB51T5 | |||||||||||
More data for this Ligand-Target Pair |