BDBM230867 US10045974, 14::US10603310, Compound 14::US9346797, 14::US9346797, 3
SMILES: COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(N=C(N)CCC1(F)F)C(F)F
InChI Key: InChIKey=ZQKVKDGKIDOTQN-SFHVURJKSA-N
Data: 6 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Beta-secretase 1 (Homo sapiens (Human)) | BDBM230867 (US10045974, 14 | US10603310, Compound 14 | US93467...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 8.5 | -11.0 | n/a | n/a | n/a | n/a | n/a | 4.5 | 25 |
H. Lundbeck A/S US Patent | Assay Description The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr... | US Patent US9346797 (2016) BindingDB Entry DOI: 10.7270/Q25T3JC4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM230867 (US10045974, 14 | US10603310, Compound 14 | US93467...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 8.5 | -11.0 | n/a | n/a | n/a | n/a | n/a | 4.5 | 25 |
H. Lundbeck A/S US Patent | Assay Description The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr... | US Patent US10045974 (2018) BindingDB Entry DOI: 10.7270/Q2T72KF3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM230867 (US10045974, 14 | US10603310, Compound 14 | US93467...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 8.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S US Patent | Assay Description The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr... | US Patent US10603310 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM230867 (US10045974, 14 | US10603310, Compound 14 | US93467...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 18 | -10.6 | n/a | n/a | n/a | n/a | n/a | 4.5 | 25 |
H. Lundbeck A/S US Patent | Assay Description The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr... | US Patent US10045974 (2018) BindingDB Entry DOI: 10.7270/Q2T72KF3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM230867 (US10045974, 14 | US10603310, Compound 14 | US93467...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S US Patent | Assay Description The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr... | US Patent US10603310 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM230867 (US10045974, 14 | US10603310, Compound 14 | US93467...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 18 | -10.6 | n/a | n/a | n/a | n/a | n/a | 4.5 | 25 |
H. Lundbeck A/S US Patent | Assay Description The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr... | US Patent US9346797 (2016) BindingDB Entry DOI: 10.7270/Q25T3JC4 | |||||||||||
More data for this Ligand-Target Pair |