BDBM231619 GSK5750

SMILES: On1c2ncccc2c(NCc2cc3ccccc3s2)nc1=O

InChI Key: InChIKey=JMKYKCCBXRBHQY-UHFFFAOYSA-N

Data: 1 IC50  1 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 231619   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...)	BDBM231619 (GSK5750) Show SMILES On1c2ncccc2c(NCc2cc3ccccc3s2)nc1=O Show InChI InChI=1S/C16H12N4O2S/c21-16-19-14(12-5-3-7-17-15(12)20(16)22)18-9-11-8-10-4-1-2-6-13(10)23-11/h1-8,22H,9H2,(H,18,19,21)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	387	n/a	n/a	n/a	7.8	n/a
McGill University					Assay Description In this case, 1 μM HIV-1 RT was added to 50 mM Tris-HCl (pH 7.8), 50 mM NaCl, 6 mM MgCl2, and varying concentrations of GSK5750 to form enzyme-i...				J Biol Chem 289: 16270-7 (2014) Article DOI: 10.1074/jbc.M114.569707 BindingDB Entry DOI: 10.7270/Q2MW2G0Q
					More data for this Ligand-Target Pair
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...)	BDBM231619 (GSK5750) Show SMILES On1c2ncccc2c(NCc2cc3ccccc3s2)nc1=O Show InChI InChI=1S/C16H12N4O2S/c21-16-19-14(12-5-3-7-17-15(12)20(16)22)18-9-11-8-10-4-1-2-6-13(10)23-11/h1-8,22H,9H2,(H,18,19,21)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	330	n/a	n/a	n/a	n/a	7.8	37
McGill University					Assay Description To compare activity and inhibition of E. coli RNase H with HIV-1 RNase H, theconcentration of the E. coli was adjusted to the efficiency of 500 nM HI...				J Biol Chem 289: 16270-7 (2014) Article DOI: 10.1074/jbc.M114.569707 BindingDB Entry DOI: 10.7270/Q2MW2G0Q
					More data for this Ligand-Target Pair