BDBM23174 6-chloro-1,2-benzoxazol-3-ol::6-chlorobenzo[d]isoxazol-3-ol::CBIO::CHEMBL445990

SMILES: Clc1ccc2c(c1)o[nH]c2=O

InChI Key: InChIKey=SJAPSPJRTQCDNO-UHFFFAOYSA-N

Data: 6 IC50  3 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 23174   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
D-Amino Acid Oxidase (DAAO) (Sus scrofa (pig))	BDBM23174 (6-chloro-1,2-benzoxazol-3-ol | 6-chlorobenzo[d]iso...) Show SMILES Clc1ccc2c(c1)o[nH]c2=O Show InChI InChI=1S/C7H4ClNO2/c8-4-1-2-5-6(3-4)11-9-7(5)10/h1-3H,(H,9,10)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	188	n/a	n/a	n/a	n/a	8.5	22
MGI Pharma					Assay Description D-amino acid oxidase (DAAO) was assayed in a 96-well plate format. D-serine was oxidatively deaminated by porcine D-amino acid oxidase in the presenc...				J Med Chem 51: 3357-9 (2008) Article DOI: 10.1021/jm800200u BindingDB Entry DOI: 10.7270/Q21G0JJJ
					More data for this Ligand-Target Pair
D-Aspartate Oxidase (DDO) (Homo sapiens (Human))	BDBM23174 (6-chloro-1,2-benzoxazol-3-ol | 6-chlorobenzo[d]iso...) Show SMILES Clc1ccc2c(c1)o[nH]c2=O Show InChI InChI=1S/C7H4ClNO2/c8-4-1-2-5-6(3-4)11-9-7(5)10/h1-3H,(H,9,10)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Curated by ChEMBL					Assay Description Inhibition of human DDO				Bioorg Med Chem Lett 18: 3386-91 (2008) Article DOI: 10.1016/j.bmcl.2008.04.020 BindingDB Entry DOI: 10.7270/Q2WQ03KS
					More data for this Ligand-Target Pair
D-amino-acid oxidase (Homo sapiens (Human))	BDBM23174 (6-chloro-1,2-benzoxazol-3-ol | 6-chlorobenzo[d]iso...) Show SMILES Clc1ccc2c(c1)o[nH]c2=O Show InChI InChI=1S/C7H4ClNO2/c8-4-1-2-5-6(3-4)11-9-7(5)10/h1-3H,(H,9,10)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	507	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Curated by ChEMBL					Assay Description Inhibition of human DAO				Bioorg Med Chem Lett 18: 3386-91 (2008) Article DOI: 10.1016/j.bmcl.2008.04.020 BindingDB Entry DOI: 10.7270/Q2WQ03KS
					More data for this Ligand-Target Pair
D-amino-acid oxidase (Homo sapiens (Human))	BDBM23174 (6-chloro-1,2-benzoxazol-3-ol | 6-chlorobenzo[d]iso...) Show SMILES Clc1ccc2c(c1)o[nH]c2=O Show InChI InChI=1S/C7H4ClNO2/c8-4-1-2-5-6(3-4)11-9-7(5)10/h1-3H,(H,9,10)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	17.2	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Healthcare Products B.V. Curated by ChEMBL					Assay Description Inhibition of human recombinant DAAO expressed in Escherichia coli assessed as H2O2 production from D-serine degradation after 30 mins by fluorescenc...				Eur J Med Chem 46: 4808-19 (2011) Article DOI: 10.1016/j.ejmech.2011.04.023 BindingDB Entry DOI: 10.7270/Q2BK1CRC
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM23174 (6-chloro-1,2-benzoxazol-3-ol | 6-chlorobenzo[d]iso...) Show SMILES Clc1ccc2c(c1)o[nH]c2=O Show InChI InChI=1S/C7H4ClNO2/c8-4-1-2-5-6(3-4)11-9-7(5)10/h1-3H,(H,9,10)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Healthcare Products B.V. Curated by ChEMBL					Assay Description Inhibition of human ERG expressed in HEK293 cells by whole cell voltage patch clamp technique				Eur J Med Chem 46: 4808-19 (2011) Article DOI: 10.1016/j.ejmech.2011.04.023 BindingDB Entry DOI: 10.7270/Q2BK1CRC
					More data for this Ligand-Target Pair
D-amino-acid oxidase (Homo sapiens (Human))	BDBM23174 (6-chloro-1,2-benzoxazol-3-ol | 6-chlorobenzo[d]iso...) Show SMILES Clc1ccc2c(c1)o[nH]c2=O Show InChI InChI=1S/C7H4ClNO2/c8-4-1-2-5-6(3-4)11-9-7(5)10/h1-3H,(H,9,10)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a
Abbott Healthcare Products B.V. Curated by ChEMBL					Assay Description Binding affinity to human recombinant DAAO by kinetic study scintillation proximity assay				Eur J Med Chem 46: 4808-19 (2011) Article DOI: 10.1016/j.ejmech.2011.04.023 BindingDB Entry DOI: 10.7270/Q2BK1CRC
					More data for this Ligand-Target Pair
D-amino-acid oxidase (Homo sapiens (Human))	BDBM23174 (6-chloro-1,2-benzoxazol-3-ol | 6-chlorobenzo[d]iso...) Show SMILES Clc1ccc2c(c1)o[nH]c2=O Show InChI InChI=1S/C7H4ClNO2/c8-4-1-2-5-6(3-4)11-9-7(5)10/h1-3H,(H,9,10)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a
Abbott Healthcare Products B.V. Curated by ChEMBL					Assay Description Binding affinity to human recombinant DAAO by steady state study scintillation proximity assay				Eur J Med Chem 46: 4808-19 (2011) Article DOI: 10.1016/j.ejmech.2011.04.023 BindingDB Entry DOI: 10.7270/Q2BK1CRC
					More data for this Ligand-Target Pair
D-aspartate oxidase (Bos taurus)	BDBM23174 (6-chloro-1,2-benzoxazol-3-ol | 6-chlorobenzo[d]iso...) Show SMILES Clc1ccc2c(c1)o[nH]c2=O Show InChI InChI=1S/C7H4ClNO2/c8-4-1-2-5-6(3-4)11-9-7(5)10/h1-3H,(H,9,10)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Healthcare Products B.V. Curated by ChEMBL					Assay Description Inhibition of bovine recombinant DASPO expressed in Escherichia coli preincubated for 15 mins by fluorescence assay				Eur J Med Chem 46: 4808-19 (2011) Article DOI: 10.1016/j.ejmech.2011.04.023 BindingDB Entry DOI: 10.7270/Q2BK1CRC
					More data for this Ligand-Target Pair
D-amino-acid oxidase (Homo sapiens (Human))	BDBM23174 (6-chloro-1,2-benzoxazol-3-ol | 6-chlorobenzo[d]iso...) Show SMILES Clc1ccc2c(c1)o[nH]c2=O Show InChI InChI=1S/C7H4ClNO2/c8-4-1-2-5-6(3-4)11-9-7(5)10/h1-3H,(H,9,10)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a
Abbott Healthcare Products B.V. Curated by ChEMBL					Assay Description Binding affinity to human recombinant DAAO by isothermal titration calorimeter analysis				Eur J Med Chem 46: 4808-19 (2011) Article DOI: 10.1016/j.ejmech.2011.04.023 BindingDB Entry DOI: 10.7270/Q2BK1CRC
					More data for this Ligand-Target Pair