BDBM232242 N-cinnamoyl-L-leucine-glycine nitrile (38)

SMILES: CC(C)C(NC(=O)\C=C\c1ccccc1)C(=O)NC(O)=O

InChI Key: InChIKey=BMCRHMOZCCGAIM-CMDGGOBGSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 232242   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cathepsin L1 (CL1) (Fasciola hepatica (Liver fluke))	BDBM232242 (N-cinnamoyl-L-leucine-glycine nitrile (38)) Show SMILES CC(C)C(NC(=O)\C=C\c1ccccc1)C(=O)NC(O)=O Show InChI InChI=1S/C15H18N2O4/c1-10(2)13(14(19)17-15(20)21)16-12(18)9-8-11-6-4-3-5-7-11/h3-10,13H,1-2H3,(H,16,18)(H,17,19)(H,20,21)/b9-8+	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Dublin City University					Assay Description The protease was activated by the addition of dithiothreitol, ethylenediaminetetraacetic acid (EDTA), and sodium acetate followed by incubation at 37...				J Enzyme Inhib Med Chem 25: 1-12 (2010) Article DOI: 10.3109/14756360902888184 BindingDB Entry DOI: 10.7270/Q29G5KP4
					More data for this Ligand-Target Pair