BDBM23226 7-{2-[4-(formamidoformic acid)-3-methoxyphenyl]ethoxy}-5-hydroxy-4-oxo-4H-chromene-2-carboxylic acid::Oxamic acid derivative, 4
SMILES: COc1cc(CCOc2cc(O)c3c(c2)oc(cc3=O)C(O)=O)ccc1NC(=O)C(O)=O
InChI Key: InChIKey=WRJYYNLHGHGXDL-UHFFFAOYSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Lactate Dehydrogenase (Plasmodium falciparum) | BDBM23226 (7-{2-[4-(formamidoformic acid)-3-methoxyphenyl]eth...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.91E+5 | n/a | n/a | n/a | n/a | 7.0 | 25 |
University of Mississippi | Assay Description LDH was assayed spectrophotometrically for reduction of pyruvate using NADH by recording the changed in absorbance at 340 nm. The reaction was initia... | J Med Chem 50: 3841-50 (2007) Article DOI: 10.1021/jm070336k BindingDB Entry DOI: 10.7270/Q2HH6HCV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Malate Dehydrogenase, mitochondrial (Sus scrofa (pig)) | BDBM23226 (7-{2-[4-(formamidoformic acid)-3-methoxyphenyl]eth...) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >2.25E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Mississippi | Assay Description MDH was assayed spectrophotometrically for reduction of oxaloacetic acid using NADH by recording the changed in absorbance at 340 nm. The reaction wa... | J Med Chem 50: 3841-50 (2007) Article DOI: 10.1021/jm070336k BindingDB Entry DOI: 10.7270/Q2HH6HCV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Malate Dehydrogenase (pfMDH) (Plasmodium falciparum) | BDBM23226 (7-{2-[4-(formamidoformic acid)-3-methoxyphenyl]eth...) | PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >2.25E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Mississippi | Assay Description MDH was assayed spectrophotometrically for reduction of oxaloacetic acid using NADH by recording the changed in absorbance at 340 nm. The reaction wa... | J Med Chem 50: 3841-50 (2007) Article DOI: 10.1021/jm070336k BindingDB Entry DOI: 10.7270/Q2HH6HCV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactate Dehydrogenase (Bos taurus (bovine)) | BDBM23226 (7-{2-[4-(formamidoformic acid)-3-methoxyphenyl]eth...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >2.25E+5 | n/a | n/a | n/a | n/a | 7.0 | 25 |
University of Mississippi | Assay Description LDH was assayed spectrophotometrically for reduction of pyruvate using NADH by recording the changed in absorbance at 340 nm. The reaction was initia... | J Med Chem 50: 3841-50 (2007) Article DOI: 10.1021/jm070336k BindingDB Entry DOI: 10.7270/Q2HH6HCV | |||||||||||
More data for this Ligand-Target Pair |