BDBM232606 US9346815, 152::US9604984, Example 152

SMILES: FC(F)Oc1ccc(Cl)cc1-c1nn(cc1NC(=O)c1cnn2cccnc12)C1CCN(CCCC(=O)NC2CCOCC2)CC1

InChI Key: InChIKey=NIVDAFZUMYCAFE-UHFFFAOYSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 232606   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM232606 (US9346815, 152 | US9604984, Example 152) Show SMILES FC(F)Oc1ccc(Cl)cc1-c1nn(cc1NC(=O)c1cnn2cccnc12)C1CCN(CCCC(=O)NC2CCOCC2)CC1 Show InChI InChI=1S/C31H35ClF2N8O4/c32-20-4-5-26(46-31(33)34)23(17-20)28-25(38-30(44)24-18-36-41-12-2-10-35-29(24)41)19-42(39-28)22-6-13-40(14-7-22)11-1-3-27(43)37-21-8-15-45-16-9-21/h2,4-5,10,12,17-19,21-22,31H,1,3,6-9,11,13-16H2,(H,37,43)(H,38,44)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.190	-13.1	n/a	n/a	n/a	n/a	n/a	7.2	22
Genentech, Inc. US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US9346815 (2016) BindingDB Entry DOI: 10.7270/Q2NS0SRT
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM232606 (US9346815, 152 | US9604984, Example 152) Show SMILES FC(F)Oc1ccc(Cl)cc1-c1nn(cc1NC(=O)c1cnn2cccnc12)C1CCN(CCCC(=O)NC2CCOCC2)CC1 Show InChI InChI=1S/C31H35ClF2N8O4/c32-20-4-5-26(46-31(33)34)23(17-20)28-25(38-30(44)24-18-36-41-12-2-10-35-29(24)41)19-42(39-28)22-6-13-40(14-7-22)11-1-3-27(43)37-21-8-15-45-16-9-21/h2,4-5,10,12,17-19,21-22,31H,1,3,6-9,11,13-16H2,(H,37,43)(H,38,44)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.190	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US9604984 (2017) BindingDB Entry DOI: 10.7270/Q26D5W25
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM232606 (US9346815, 152 | US9604984, Example 152) Show SMILES FC(F)Oc1ccc(Cl)cc1-c1nn(cc1NC(=O)c1cnn2cccnc12)C1CCN(CCCC(=O)NC2CCOCC2)CC1 Show InChI InChI=1S/C31H35ClF2N8O4/c32-20-4-5-26(46-31(33)34)23(17-20)28-25(38-30(44)24-18-36-41-12-2-10-35-29(24)41)19-42(39-28)22-6-13-40(14-7-22)11-1-3-27(43)37-21-8-15-45-16-9-21/h2,4-5,10,12,17-19,21-22,31H,1,3,6-9,11,13-16H2,(H,37,43)(H,38,44)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.08	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US9604984 (2017) BindingDB Entry DOI: 10.7270/Q26D5W25
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM232606 (US9346815, 152 | US9604984, Example 152) Show SMILES FC(F)Oc1ccc(Cl)cc1-c1nn(cc1NC(=O)c1cnn2cccnc12)C1CCN(CCCC(=O)NC2CCOCC2)CC1 Show InChI InChI=1S/C31H35ClF2N8O4/c32-20-4-5-26(46-31(33)34)23(17-20)28-25(38-30(44)24-18-36-41-12-2-10-35-29(24)41)19-42(39-28)22-6-13-40(14-7-22)11-1-3-27(43)37-21-8-15-45-16-9-21/h2,4-5,10,12,17-19,21-22,31H,1,3,6-9,11,13-16H2,(H,37,43)(H,38,44)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.08	-12.1	n/a	n/a	n/a	n/a	n/a	7.2	22
Genentech, Inc. US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US9346815 (2016) BindingDB Entry DOI: 10.7270/Q2NS0SRT
					More data for this Ligand-Target Pair