BDBM232640 US9346815, 186::US9604984, Example 186

SMILES: Nc1nn2cccnc2c1C(=O)Nc1cn(nc1-c1cc(Cl)ccc1OC(F)F)[C@H]1CCNC1

InChI Key: InChIKey=YZMIQTVIZUMJRU-LBPRGKRZSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 232640   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM232640 (US9346815, 186 | US9604984, Example 186) Show SMILES Nc1nn2cccnc2c1C(=O)Nc1cn(nc1-c1cc(Cl)ccc1OC(F)F)[C@H]1CCNC1 |r| Show InChI InChI=1S/C21H19ClF2N8O2/c22-11-2-3-15(34-21(23)24)13(8-11)17-14(10-32(29-17)12-4-6-26-9-12)28-20(33)16-18(25)30-31-7-1-5-27-19(16)31/h1-3,5,7-8,10,12,21,26H,4,6,9H2,(H2,25,30)(H,28,33)/t12-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.200	-13.1	n/a	n/a	n/a	n/a	n/a	7.2	22
Genentech, Inc. US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US9346815 (2016) BindingDB Entry DOI: 10.7270/Q2NS0SRT
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM232640 (US9346815, 186 | US9604984, Example 186) Show SMILES Nc1nn2cccnc2c1C(=O)Nc1cn(nc1-c1cc(Cl)ccc1OC(F)F)[C@H]1CCNC1 |r| Show InChI InChI=1S/C21H19ClF2N8O2/c22-11-2-3-15(34-21(23)24)13(8-11)17-14(10-32(29-17)12-4-6-26-9-12)28-20(33)16-18(25)30-31-7-1-5-27-19(16)31/h1-3,5,7-8,10,12,21,26H,4,6,9H2,(H2,25,30)(H,28,33)/t12-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US9604984 (2017) BindingDB Entry DOI: 10.7270/Q26D5W25
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM232640 (US9346815, 186 | US9604984, Example 186) Show SMILES Nc1nn2cccnc2c1C(=O)Nc1cn(nc1-c1cc(Cl)ccc1OC(F)F)[C@H]1CCNC1 |r| Show InChI InChI=1S/C21H19ClF2N8O2/c22-11-2-3-15(34-21(23)24)13(8-11)17-14(10-32(29-17)12-4-6-26-9-12)28-20(33)16-18(25)30-31-7-1-5-27-19(16)31/h1-3,5,7-8,10,12,21,26H,4,6,9H2,(H2,25,30)(H,28,33)/t12-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.710	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US9604984 (2017) BindingDB Entry DOI: 10.7270/Q26D5W25
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM232640 (US9346815, 186 | US9604984, Example 186) Show SMILES Nc1nn2cccnc2c1C(=O)Nc1cn(nc1-c1cc(Cl)ccc1OC(F)F)[C@H]1CCNC1 |r| Show InChI InChI=1S/C21H19ClF2N8O2/c22-11-2-3-15(34-21(23)24)13(8-11)17-14(10-32(29-17)12-4-6-26-9-12)28-20(33)16-18(25)30-31-7-1-5-27-19(16)31/h1-3,5,7-8,10,12,21,26H,4,6,9H2,(H2,25,30)(H,28,33)/t12-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.710	-12.3	n/a	n/a	n/a	n/a	n/a	7.2	22
Genentech, Inc. US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US9346815 (2016) BindingDB Entry DOI: 10.7270/Q2NS0SRT
					More data for this Ligand-Target Pair