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BDBM232738 US9346815, 284::US9604984, Example 284

SMILES: FC(F)Oc1ccc(Cl)cc1-c1nn(CC(=O)N2CCC=CC2)cc1NC(=O)c1cnn2cccnc12

InChI Key: InChIKey=OGXOLQPJELKLOU-UHFFFAOYSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 232738   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM232738
PNG
(US9346815, 284 | US9604984, Example 284)
Show SMILES FC(F)Oc1ccc(Cl)cc1-c1nn(CC(=O)N2CCC=CC2)cc1NC(=O)c1cnn2cccnc12 |c:21|
Show InChI InChI=1S/C24H20ClF2N7O3/c25-15-5-6-19(37-24(26)27)16(11-15)21-18(13-33(31-21)14-20(35)32-8-2-1-3-9-32)30-23(36)17-12-29-34-10-4-7-28-22(17)34/h1-2,4-7,10-13,24H,3,8-9,14H2,(H,30,36)
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PC cid
PC sid
UniChem
US Patent
0.150n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent




US Patent US9604984 (2017)


BindingDB Entry DOI: 10.7270/Q26D5W25
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM232738
PNG
(US9346815, 284 | US9604984, Example 284)
Show SMILES FC(F)Oc1ccc(Cl)cc1-c1nn(CC(=O)N2CCC=CC2)cc1NC(=O)c1cnn2cccnc12 |c:21|
Show InChI InChI=1S/C24H20ClF2N7O3/c25-15-5-6-19(37-24(26)27)16(11-15)21-18(13-33(31-21)14-20(35)32-8-2-1-3-9-32)30-23(36)17-12-29-34-10-4-7-28-22(17)34/h1-2,4-7,10-13,24H,3,8-9,14H2,(H,30,36)
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US Patent
0.150 -13.3n/an/an/an/an/a7.222



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9346815 (2016)


BindingDB Entry DOI: 10.7270/Q2NS0SRT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232738
PNG
(US9346815, 284 | US9604984, Example 284)
Show SMILES FC(F)Oc1ccc(Cl)cc1-c1nn(CC(=O)N2CCC=CC2)cc1NC(=O)c1cnn2cccnc12 |c:21|
Show InChI InChI=1S/C24H20ClF2N7O3/c25-15-5-6-19(37-24(26)27)16(11-15)21-18(13-33(31-21)14-20(35)32-8-2-1-3-9-32)30-23(36)17-12-29-34-10-4-7-28-22(17)34/h1-2,4-7,10-13,24H,3,8-9,14H2,(H,30,36)
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US Patent
0.370n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent




US Patent US9604984 (2017)


BindingDB Entry DOI: 10.7270/Q26D5W25
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232738
PNG
(US9346815, 284 | US9604984, Example 284)
Show SMILES FC(F)Oc1ccc(Cl)cc1-c1nn(CC(=O)N2CCC=CC2)cc1NC(=O)c1cnn2cccnc12 |c:21|
Show InChI InChI=1S/C24H20ClF2N7O3/c25-15-5-6-19(37-24(26)27)16(11-15)21-18(13-33(31-21)14-20(35)32-8-2-1-3-9-32)30-23(36)17-12-29-34-10-4-7-28-22(17)34/h1-2,4-7,10-13,24H,3,8-9,14H2,(H,30,36)
PDB

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UniProtKB/SwissProt

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antibodypedia
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PC cid
PC sid
UniChem
US Patent
0.370 -12.7n/an/an/an/an/a7.222



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9346815 (2016)


BindingDB Entry DOI: 10.7270/Q2NS0SRT
More data for this
Ligand-Target Pair