BDBM232781 US9346815, 327::US9604984, Example 327

SMILES: Oc1cccc(CNCCn2cc(NC(=O)c3cnn4cccnc34)c(n2)-c2cc(Cl)ccc2OC(F)F)c1

InChI Key: InChIKey=GSLRMDBWPNBYFD-UHFFFAOYSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 232781   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM232781 (US9346815, 327 | US9604984, Example 327) Show SMILES Oc1cccc(CNCCn2cc(NC(=O)c3cnn4cccnc34)c(n2)-c2cc(Cl)ccc2OC(F)F)c1 Show InChI InChI=1S/C26H22ClF2N7O3/c27-17-5-6-22(39-26(28)29)19(12-17)23-21(33-25(38)20-14-32-36-9-2-7-31-24(20)36)15-35(34-23)10-8-30-13-16-3-1-4-18(37)11-16/h1-7,9,11-12,14-15,26,30,37H,8,10,13H2,(H,33,38)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.200	-13.1	n/a	n/a	n/a	n/a	n/a	7.2	22
Genentech, Inc. US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US9346815 (2016) BindingDB Entry DOI: 10.7270/Q2NS0SRT
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM232781 (US9346815, 327 | US9604984, Example 327) Show SMILES Oc1cccc(CNCCn2cc(NC(=O)c3cnn4cccnc34)c(n2)-c2cc(Cl)ccc2OC(F)F)c1 Show InChI InChI=1S/C26H22ClF2N7O3/c27-17-5-6-22(39-26(28)29)19(12-17)23-21(33-25(38)20-14-32-36-9-2-7-31-24(20)36)15-35(34-23)10-8-30-13-16-3-1-4-18(37)11-16/h1-7,9,11-12,14-15,26,30,37H,8,10,13H2,(H,33,38)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US9604984 (2017) BindingDB Entry DOI: 10.7270/Q26D5W25
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM232781 (US9346815, 327 | US9604984, Example 327) Show SMILES Oc1cccc(CNCCn2cc(NC(=O)c3cnn4cccnc34)c(n2)-c2cc(Cl)ccc2OC(F)F)c1 Show InChI InChI=1S/C26H22ClF2N7O3/c27-17-5-6-22(39-26(28)29)19(12-17)23-21(33-25(38)20-14-32-36-9-2-7-31-24(20)36)15-35(34-23)10-8-30-13-16-3-1-4-18(37)11-16/h1-7,9,11-12,14-15,26,30,37H,8,10,13H2,(H,33,38)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.25	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US9604984 (2017) BindingDB Entry DOI: 10.7270/Q26D5W25
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM232781 (US9346815, 327 | US9604984, Example 327) Show SMILES Oc1cccc(CNCCn2cc(NC(=O)c3cnn4cccnc34)c(n2)-c2cc(Cl)ccc2OC(F)F)c1 Show InChI InChI=1S/C26H22ClF2N7O3/c27-17-5-6-22(39-26(28)29)19(12-17)23-21(33-25(38)20-14-32-36-9-2-7-31-24(20)36)15-35(34-23)10-8-30-13-16-3-1-4-18(37)11-16/h1-7,9,11-12,14-15,26,30,37H,8,10,13H2,(H,33,38)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.25	-13.0	n/a	n/a	n/a	n/a	n/a	7.2	22
Genentech, Inc. US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US9346815 (2016) BindingDB Entry DOI: 10.7270/Q2NS0SRT
					More data for this Ligand-Target Pair