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BDBM23392 N-(6-chloropyridin-3-yl)-6-methoxy-12-oxo-11,17-diazatetracyclo[11.3.1.0^{2,11}.0^{3,8}]heptadeca-3(8),4,6-triene-17-sulfonamide::Tetracyclic aza-amide, 14f

SMILES: COc1ccc2C3C4CCCC(N4S(=O)(=O)Nc4ccc(Cl)nc4)C(=O)N3CCc2c1

InChI Key: InChIKey=KSWUGODYBAZZFD-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 23392   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Immunophilin FKBP12


(Bos taurus (bovine))
BDBM23392
PNG
(N-(6-chloropyridin-3-yl)-6-methoxy-12-oxo-11,17-di...)
Show SMILES COc1ccc2C3C4CCCC(N4S(=O)(=O)Nc4ccc(Cl)nc4)C(=O)N3CCc2c1 |TLB:13:12:8.9.10:26.6.24|
Show InChI InChI=1S/C21H23ClN4O4S/c1-30-15-6-7-16-13(11-15)9-10-25-20(16)17-3-2-4-18(21(25)27)26(17)31(28,29)24-14-5-8-19(22)23-12-14/h5-8,11-12,17-18,20,24H,2-4,9-10H2,1H3
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Article
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360n/an/an/an/an/an/an/an/a



Pfizer



Assay Description
PPIase(Rotamase) activity of FKBP12 was assayed using the peptide N-succinyl Ala-Leu-Pro-Phe p-nitroanilide as substrate. It is based on the observat...


J Med Chem 49: 1202-6 (2006)


Article DOI: 10.1021/jm049161u
BindingDB Entry DOI: 10.7270/Q2BR8QG9
More data for this
Ligand-Target Pair