null
SMILES: C[C@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@H](O[C@@H]3[C@@H](CO)OC(O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1N[C@H]1C=C(CO)[C@@H](O)[C@H](O)[C@H]1O
InChI Key: InChIKey=XUFXOAAUWZOOIT-UGEKTDRHSA-N
PDB links: 17 PDB IDs match this monomer. 2 PDB IDs contain this monomer as substructures. 2 PDB IDs contain inhibitors having a similarity of 90% to this monomer.
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Maltase-glucoamylase (Homo sapiens) | BDBM23406 ((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucan 1,4-alpha-glucosidase (Shiitake mushroom) | BDBM23406 ((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...) | UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | 126 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Using the samples prepared according to Example 1 and Comparative Examples 2 and 3, inhibitory activity against α-glucosidase was evaluated to a... | Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JDW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-amylase 1A (Homo sapiens (Human)) | BDBM23406 ((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 996 | n/a | n/a | n/a | n/a | 6.0 | 22 |
Nestle Research Center | Assay Description The assay was carried out at room temperature for 10 min with salivary alpha-amylase, starch, and test compounds. The reducing sugar was determined b... | J Med Chem 51: 3555-61 (2008) Article DOI: 10.1021/jm800115x BindingDB Entry DOI: 10.7270/Q237771Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pancreatic alpha-amylase (Sus scrofa (Pig)) | BDBM23406 ((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 1.35E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dammam Curated by ChEMBL | Assay Description Inhibition of porcine pancreatic alpha-amylase using starch as substrate preincubated for 10 mins followed by substrate addition measured after 10 mi... | Eur J Med Chem 141: 530-537 (2017) Article DOI: 10.1016/j.ejmech.2017.10.028 BindingDB Entry DOI: 10.7270/Q27M0BM6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pancreatic alpha-amylase (Sus scrofa (Pig)) | BDBM23406 ((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 1.66E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of porcine pancreatic alpha-amylase using 1% starch as substrate preincubated for 10 mins followed by substrate addition and measured afte... | Citation and Details Article DOI: 10.1016/j.ejmech.2020.112994 BindingDB Entry DOI: 10.7270/Q2CC14FP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Probable maltase-glucoamylase 2 (Homo sapiens) | BDBM23406 ((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Karachi Curated by ChEMBL | Assay Description Inhibition of alpha-glucosidase (unknown origin) | Eur J Med Chem 183: (2019) Article DOI: 10.1016/j.ejmech.2019.111677 BindingDB Entry DOI: 10.7270/Q2KH0RSG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-amylase (Acarus siro (Flour mite)) | BDBM23406 ((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 3.80E+3 | n/a | n/a | n/a | n/a | 4.5 | n/a |
Academy of Sciences of the Czech Republic | Assay Description α-Amylase activity was assayed with the chromogenic substrate RBB-starch. An enzyme aliquot was incubated (20 min, 26°C) with 0.3% RBB-starch in... | BMC Biochem 13: 3 (2012) Article DOI: 10.1186/1471-2091-13-3 BindingDB Entry DOI: 10.7270/Q2DZ074P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pancreatic alpha-amylase (Sus scrofa (Pig)) | BDBM23406 ((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 5.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, Liaoning, China. Curated by ChEMBL | Assay Description Inhibition of porcine pancreatic alpha-amylase using starch as substrate preincubated for 15 mins followed by substrate addition measured after 10 mi... | Bioorg Med Chem Lett 27: 5065-5070 (2017) Article DOI: 10.1016/j.bmcl.2017.09.027 BindingDB Entry DOI: 10.7270/Q2Q81GJ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pancreatic alpha-amylase (Sus scrofa (Pig)) | BDBM23406 ((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 8.93E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
CSIR-National Institute for Interdisciplinary Science and Technology Curated by ChEMBL | Assay Description Inhibition of porcine pancreatic alpha-amylase using starch as substrate after 30 mins by iodine reagent based assay | Bioorg Med Chem 26: 3461-3467 (2018) Article DOI: 10.1016/j.bmc.2018.05.020 BindingDB Entry DOI: 10.7270/Q2NS0XD0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Oligo-1,6-glucosidase IMA1 (Saccharomyces cerevisiae S288c (Baker's yeast)) | BDBM23406 ((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 9.37E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
King Abdulaziz University | Assay Description α-Glucosidase inhibitory activity was evaluated at 37 °C, by using 0.1M phosphatebuffer (pH6.8) [28]. The enzyme(EC3.2.1.20, Saccharomyces cerev... | Bioorg Chem 65: 61-72 (2016) Article DOI: 10.1016/j.bioorg.2016.01.008 BindingDB Entry DOI: 10.7270/Q2V123JW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mannosyl-oligosaccharide glucosidase (Saccharomyces cerevisiae (Yeast)) | BDBM23406 ((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 1.33E+4 | n/a | n/a | n/a | n/a | 6.8 | n/a |
Recep Tayyip Erdogan University | Assay Description α-Glucosidase inhibition assay was performed spectrophotometrically. α-Glucosidase from Saccharomyces cerevisiae (Sigma-Aldrich) was dissol... | Bioorg Chem 68: 226-35 (2016) Article DOI: 10.1016/j.bioorg.2016.08.011 BindingDB Entry DOI: 10.7270/Q20C4TKG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysosomal alpha-glucosidase (Mus musculus (Mouse)) | BDBM23406 ((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 1.36E+4 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Shiraz University | Assay Description In this study, the inhibition assay of yeast enzyme was performed in 100 mM phosphate buffer pH 7.0 at 25°C with minor changes, according to the meth... | J Enzyme Inhib Med Chem 28: 1228-35 (2013) Article DOI: 10.3109/14756366.2012.727812 BindingDB Entry DOI: 10.7270/Q2XP73V0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Maltase-glucoamylase (Homo sapiens (Human)) | BDBM23406 ((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 1.52E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human intestinal maltase using maltose as substrate incubated for 30 mins and immediately heated for 2 mins by glucose oxidase method | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127751 BindingDB Entry DOI: 10.7270/Q22B92NF | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Sucrase-isomaltase, intestinal (Rattus norvegicus (Rat)) | BDBM23406 ((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 2.02E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of sucrase in rat small intestinal mucosa assessed as reduction in glucose production using sucrose as substrate measured after 40 mins by... | Eur J Med Chem 127: 1035-1046 (2017) Article DOI: 10.1016/j.ejmech.2016.11.015 BindingDB Entry DOI: 10.7270/Q290260N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Maltase-glucoamylase (Homo sapiens) | BDBM23406 ((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | n/a | n/a | 2.44E+4 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pancreatic alpha-amylase (Sus scrofa (Pig)) | BDBM23406 ((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 2.63E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi della Basilicata Curated by ChEMBL | Assay Description Inhibition of hog pancreas alpha-amylase using starch as substrate preincubated for 10 mins followed by substrate addition measured after 10 mins by ... | J Nat Prod 79: 2104-12 (2016) Article DOI: 10.1021/acs.jnatprod.6b00484 BindingDB Entry DOI: 10.7270/Q2QN68R4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Oligo-1,6-glucosidase IMA1 (Saccharomyces cerevisiae S288c (Baker's yeast)) | BDBM23406 ((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 3.83E+4 | n/a | n/a | n/a | n/a | 6.8 | n/a |
GC University | Assay Description The α-glucosidase inhibition activity was performed with slight modifications according to method. Total volume of 100 µL reaction mixture conta... | Bioorg Chem 63: 64-71 (2015) Article DOI: 10.1016/j.bioorg.2015.09.008 BindingDB Entry DOI: 10.7270/Q2RJ4H7T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Oligo-1,6-glucosidase IMA1 (Saccharomyces cerevisiae S288c (Baker's yeast)) | BDBM23406 ((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 3.83E+4 | n/a | n/a | n/a | n/a | 6.8 | n/a |
Universiti Teknologi MARA | Assay Description The α-glucosidase inhibition assay had been carried out using baker¿s yeast a-glucosidase (EC 3.2.1.20) and p-nitrophenyl-α-D-glucopyranosi... | Chem Biol Drug Des 87: 361-73 (2016) Article DOI: 10.1111/cbdd.12666 BindingDB Entry DOI: 10.7270/Q2HQ3XPS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Oligo-1,6-glucosidase IMA1 (Saccharomyces cerevisiae S288c (Baker's yeast)) | BDBM23406 ((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 3.83E+4 | n/a | n/a | n/a | n/a | 6.8 | 37 |
University of the Punjab | Assay Description The enzyme assays were done in the initial linear parts of the assay curve with suitable positive and negative controls (data not shown). A total of ... | Bioorg Chem 71: 170-180 (2017) Article DOI: 10.1016/j.bioorg.2017.02.003 BindingDB Entry DOI: 10.7270/Q29G5KNP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Oligo-1,6-glucosidase IMA1 (Saccharomyces cerevisiae S288c (Baker's yeast)) | BDBM23406 ((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 3.83E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of the Punjab; Kinnaird College for Women | Assay Description At 37 °C, after incubation of 10 min of a reaction mixture solution of 70 μL (50 mM) phosphate buffer of 6.8 pH, 10 μL (0.5 mM) of a test c... | Bioorg Chem 71: 102-109 (2017) Article DOI: 10.1016/j.bioorg.2017.01.017 BindingDB Entry DOI: 10.7270/Q2Z89B86 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-glucosidase MAL32 (Saccharomyces cerevisiae (Baker's yeast)) | BDBM23406 ((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 3.83E+4 | n/a | n/a | n/a | n/a | 6.8 | 37 |
Kinnaird College for Women | Assay Description For α-glucosidase inhibition assay, α-glucosidase enzyme (Cat No. 5003-1KU Type I; isolated from Saccharomyces cereviciae) was used. Acarbo... | Bioorg Chem 73: 1-9 (2017) Article DOI: 10.1016/j.bioorg.2017.05.009 BindingDB Entry DOI: 10.7270/Q2TD9W62 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-glucosidase MAL12 (Saccharomyces cerevisiae) | BDBM23406 ((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 4.33E+4 | n/a | n/a | n/a | n/a | 6.8 | n/a |
Jishou University | Assay Description The test compounds were dissolved in DMSO to prepare the required distributing concentration. α-Glucosidase inhibitory activity was assayed by u... | Bioorg Chem 65: 167-74 (2016) Article DOI: 10.1016/j.bioorg.2016.03.001 BindingDB Entry DOI: 10.7270/Q2445K8R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Probable maltase-glucoamylase 2 (Homo sapiens) | BDBM23406 ((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 8.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wollongong Curated by ChEMBL | Assay Description Inhibition of alpha-glucosidase (unknown origin) using p-nitrophenyl alpha-D-glucoside as substrate preincubated for 0.5 hrs followed substrate addit... | J Nat Prod 83: 164-168 (2020) Article DOI: 10.1021/acs.jnatprod.9b00849 BindingDB Entry DOI: 10.7270/Q2ST7T5V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Probable maltase-glucoamylase 2 (Homo sapiens) | BDBM23406 ((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 1.02E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Hebei University Curated by ChEMBL | Assay Description Inhibition of alpha-glucosidase (unknown origin) using p-nitrophenyl glycoside as substrate treated 20 mins post substrate addition measured for 1 mi... | J Nat Prod 80: 2199-2203 (2017) Article DOI: 10.1021/acs.jnatprod.7b00032 BindingDB Entry DOI: 10.7270/Q20P12MS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-glucosidase MAL32 (Saccharomyces cerevisiae) | BDBM23406 ((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 1.31E+5 | n/a | n/a | n/a | n/a | 6.8 | 1 |
CSIR-Indian Institute of Chemical Biology | Assay Description Briefly, the sample solution (25 μL, 1.0 mM solution in DMSO) was mixed with enzyme solution (25 μL, 0.5 U/mL prepared in 0.1 M phosphate buffe... | Bioorg Chem 72: 11-20 (2017) Article DOI: 10.1016/j.bioorg.2017.03.006 BindingDB Entry DOI: 10.7270/Q2D7999X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-binding cassette sub-family C member 2 (Homo sapiens (Human)) | BDBM23406 ((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >1.33E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc Curated by ChEMBL | Assay Description Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and... | Toxicol Sci 136: 216-41 (2013) Article DOI: 10.1093/toxsci/kft176 BindingDB Entry DOI: 10.7270/Q2JM2D2D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-binding cassette sub-family C member 3 (Homo sapiens (Human)) | BDBM23406 ((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >1.33E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc Curated by ChEMBL | Assay Description Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ... | Toxicol Sci 136: 216-41 (2013) Article DOI: 10.1093/toxsci/kft176 BindingDB Entry DOI: 10.7270/Q2JM2D2D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-binding cassette sub-family C member 4 (Homo sapiens (Human)) | BDBM23406 ((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >1.33E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc Curated by ChEMBL | Assay Description Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and... | Toxicol Sci 136: 216-41 (2013) Article DOI: 10.1093/toxsci/kft176 BindingDB Entry DOI: 10.7270/Q2JM2D2D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bile salt export pump (Homo sapiens (Human)) | BDBM23406 ((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >1.33E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc Curated by ChEMBL | Assay Description Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ... | Toxicol Sci 136: 216-41 (2013) Article DOI: 10.1093/toxsci/kft176 BindingDB Entry DOI: 10.7270/Q2JM2D2D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-glucosidase MAL12 (Saccharomyces cerevisiae) | BDBM23406 ((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 2.75E+5 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Shiraz University | Assay Description In this study, the inhibition assay of yeast enzyme was performed in 100 mM phosphate buffer pH 7.0 at 25°C with minor changes, according to the meth... | J Enzyme Inhib Med Chem 28: 1228-35 (2013) Article DOI: 10.3109/14756366.2012.727812 BindingDB Entry DOI: 10.7270/Q2XP73V0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Probable maltase-glucoamylase 2 (Homo sapiens) | BDBM23406 ((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 3.20E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of alpha-glucosidase (unknown origin) using p-nitro-phenyl-alpha-D-glucopyranoside as substrate preincubated for 5 mins with substrate fol... | Citation and Details Article DOI: 10.1016/j.bmcl.2017.12.049 BindingDB Entry DOI: 10.7270/Q2Q52S6T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysosomal alpha-glucosidase/Maltase-glucoamylase/Probable maltase-glucoamylase 2/Sucrase-isomaltase, intestinal (Homo sapiens (Human)) | BDBM23406 ((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 4.42E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research Curated by ChEMBL | Assay Description Inhibition of alpha-glucosidase (unknown origin) using p-NPG as substrate pretreated for 10 mins followed by substrate addition measured after 5 mins | J Nat Prod 80: 2923-2929 (2017) Article DOI: 10.1021/acs.jnatprod.7b00457 BindingDB Entry DOI: 10.7270/Q2CJ8H0S | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Probable maltase-glucoamylase 2 (Homo sapiens) | BDBM23406 ((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 7.08E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Ocean University of China Curated by ChEMBL | Assay Description Inhibition of human alpha-glucosidase expressed in Saccharomyces cerevisiae using p-nitrophenyl-alpha-D-glucopyranoside as substrate after 15 mins | Eur J Med Chem 146: 232-244 (2018) Article DOI: 10.1016/j.ejmech.2018.01.057 BindingDB Entry DOI: 10.7270/Q29P3494 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Oligo-1,6-glucosidase IMA1 (Saccharomyces cerevisiae S288c (Baker's yeast)) | BDBM23406 ((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 7.75E+5 | n/a | n/a | n/a | n/a | 6.8 | n/a |
Universiti Teknologi MARA (UiTM) | Assay Description The enzyme inhibition was evaluated according to the method previously reported by Rahim et al. [25] with slight modification. Various concentration ... | Bioorg Chem 64: 29-36 (2016) Article DOI: 10.1016/j.bioorg.2015.11.006 BindingDB Entry DOI: 10.7270/Q2W37V2M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Oligo-1,6-glucosidase IMA1 (Saccharomyces cerevisiae S288c (Baker's yeast)) | BDBM23406 ((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 7.75E+5 | n/a | n/a | n/a | n/a | 6.8 | 37 |
Universiti Teknologi MARA (UiTM) | Assay Description The enzyme inhibition was evaluated according to the method previously reported by Zawawi et al. [Zawawi et al., Bioorg. Chem., 23:3119] with slight ... | Bioorg Chem 70: 184-191 (2017) Article DOI: 10.1016/j.bioorg.2016.12.009 BindingDB Entry DOI: 10.7270/Q27P8X71 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Probable maltase-glucoamylase 2 (Homo sapiens) | BDBM23406 ((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 8.17E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Babasaheb Bhimrao Ambedkar University (A Central University) Curated by ChEMBL | Assay Description Inhibition of alpha-glucosidase (unknown origin) using p-nitrophenyl-alpha-d-glucopyranoside as substrate preincubated for 15 mins followed by substr... | Eur J Med Chem 176: 343-377 (2019) Article DOI: 10.1016/j.ejmech.2019.04.025 BindingDB Entry DOI: 10.7270/Q2N87F09 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysosomal alpha-glucosidase (Homo sapiens (Human)) | BDBM23406 ((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...) | PDB NCI pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 8.17E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Jishou University Curated by ChEMBL | Assay Description Inhibition of alpha-glucosidase (unknown origin) using p-nitrophenyl-alpha-D-glucopyranoside as substrate preincubated for 15 mins followed by substr... | Eur J Med Chem 125: 423-429 (2017) Article DOI: 10.1016/j.ejmech.2016.09.067 BindingDB Entry DOI: 10.7270/Q2HD7Z30 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-glucosidase MAL32 (Saccharomyces cerevisiae) | BDBM23406 ((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 8.17E+5 | n/a | n/a | n/a | n/a | 6.8 | n/a |
Jishou University | Assay Description The test compounds were dissolved in DMSO to prepare the required distributing concentration. α-Glucosidase inhibitory activity was assayed usin... | Chem Biol Drug Des 89: 456-463 (2017) Article DOI: 10.1111/cbdd.12867 BindingDB Entry DOI: 10.7270/Q25M64KX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Oligo-1,6-glucosidase IMA1 (Saccharomyces cerevisiae S288c (Baker's yeast)) | BDBM23406 ((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 8.17E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Jishou University Curated by ChEMBL | Assay Description Inhibition of bakers yeast alpha-glucosidase using p-nitrophenyl-alpha-D-glucopyranoside as substrate incubated for 15 mins followed by substrate add... | Bioorg Med Chem Lett 26: 5719-5723 (2016) Article DOI: 10.1016/j.bmcl.2016.10.057 BindingDB Entry DOI: 10.7270/Q2SF2Z4C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Probable maltase-glucoamylase 2 (Homo sapiens) | BDBM23406 ((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 8.17E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Maharaja Ranjit Singh Punjab Technical University Curated by ChEMBL | Assay Description Inhibition of alpha-glucosidase (unknown origin) using p-nitrophenyl alpha-d-glucopyranoside as substrate preincubated for 15 mins followed by substr... | Eur J Med Chem 180: 486-508 (2019) Article DOI: 10.1016/j.ejmech.2019.07.043 BindingDB Entry DOI: 10.7270/Q2959N1V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-glucosidase MAL32 (Saccharomyces cerevisiae) | BDBM23406 ((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | n/a | n/a | 8.17E+5 | n/a | n/a | n/a | n/a | 6.8 | 37 | |
Jishou University | Assay Description The α-glucosidase inhibition assay had been carried out using baker's yeast α-glucosidase (EC 3.2.1.20) and p-nitrophenyl α-d-gluco... | Bioorg Chem 72: 228-233 (2017) BindingDB Entry DOI: 10.7270/Q2DV1HSV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Oligo-1,6-glucosidase IMA1 (Saccharomyces cerevisiae S288c (Baker's yeast)) | BDBM23406 ((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 8.56E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universiti Teknologi MARA (UiTM), Puncak Alam Campus | Assay Description The 135 µL of 50 mM phosphate saline buffer pH (6.8), solution of enzyme (20 µL), and 20 µL of test sample with 70% DMSO was added to 96-well plate. ... | Bioorg Chem 65: 100-9 (2016) Article DOI: 10.1016/j.bioorg.2016.02.004 BindingDB Entry DOI: 10.7270/Q24B303S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-glucosidase MAL12 (Saccharomyces cerevisiae) | BDBM23406 ((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 9.08E+5 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Kinki University | Assay Description α-glucosidase (25 μL, 0.2 U/mL), 25 μL of various concentrations of samples, and 175 μL of 50 mM sodium phosphate buffer (pH 7.0)... | J Enzyme Inhib Med Chem 28: 1162-70 (2013) Article DOI: 10.3109/14756366.2012.719503 BindingDB Entry DOI: 10.7270/Q22F7MCR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Probable maltase-glucoamylase 2 (Homo sapiens) | BDBM23406 ((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 9.42E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Babasaheb Bhimrao Ambedkar University (A Central University) Curated by ChEMBL | Assay Description Inhibition of alpha-glucosidase (unknown origin) using p-nitrophenyl-alpha-d-glucopyranoside as substrate preincubated for 15 mins followed by substr... | Eur J Med Chem 176: 343-377 (2019) Article DOI: 10.1016/j.ejmech.2019.04.025 BindingDB Entry DOI: 10.7270/Q2N87F09 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-xylosidase (Blautia obeum) | BDBM23406 ((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 1.03E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad Nacional Aut£noma de M£xico Curated by ChEMBL | Assay Description Inhibition of recombinant Ruminococcus obeum ATCC 29174 alpha-glucosidase expressed in Escherichia coli BL21(DE3) using p-nitrophenyl-alpha-D-glucopy... | J Nat Prod 80: 1584-1593 (2017) Article DOI: 10.1021/acs.jnatprod.7b00155 BindingDB Entry DOI: 10.7270/Q2571FH2 | |||||||||||
More data for this Ligand-Target Pair |