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BDBM23417 α-CA inhibitor, 4::(-)-Epicatechin::(2R,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3,5,7-triol::Epicatechin::L-Epicatechin::cid_72276
SMILES: O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c1ccc(O)c(O)c1
InChI Key: InChIKey=PFTAWBLQPZVEMU-UKRRQHHQSA-N
Data: 7 KI 19 IC50 2 Kd 3 EC50 1 Other
PDB links: 4 PDB IDs match this monomer. 4 PDB IDs contain this monomer as substructures. 4 PDB IDs contain inhibitors having a similarity of 90% to this monomer.
| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Apoptosis regulator Bcl-2 (Homo sapiens (Human)) | BDBM23417 (α-CA inhibitor, 4 | (-)-Epicatechin | (2R,3R)...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet  | Purchase KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article | >1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of NLWAAQRYGRELRRMSD-K(FITC)-FVD from Bcl-2 (unknown origin) by fluorescence polarization assay | Citation and Details Article DOI: 10.1007/s00044-009-9233-5 BindingDB Entry DOI: 10.7270/Q27M0BVB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Arginase (Leishmania amazonensis) | BDBM23417 (α-CA inhibitor, 4 | (-)-Epicatechin | (2R,3R)...) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade Federal de S£o Carlos Curated by ChEMBL | Assay Description Noncompetitive inhibition of Leishmania amazonensis recombinant arginase expressed in Escherichia coli Rosetta (DE3) pLysS using L-arginine as substr... | J Nat Prod 77: 392-6 (2014) Article DOI: 10.1021/np400717m BindingDB Entry DOI: 10.7270/Q2VX0J09 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Carbonic anhydrase 2 (Homo sapiens (Human)) | BDBM23417 (α-CA inhibitor, 4 | (-)-Epicatechin | (2R,3R)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 1.24E+3 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Ege University | Assay Description CA activity was assayed by following the change in absorbance at 348 nm of 4-NPA to 4-nitrophenylate ion over a period of 3 min at 25°C using a spect... | J Enzyme Inhib Med Chem 28: 412-7 (2013) Article DOI: 10.3109/14756366.2011.651464 BindingDB Entry DOI: 10.7270/Q2W66JQ2 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Carbonic anhydrase 1 (Homo sapiens (Human)) | BDBM23417 (α-CA inhibitor, 4 | (-)-Epicatechin | (2R,3R)...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 2.32E+3 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Ege University | Assay Description CA activity was assayed by following the change in absorbance at 348 nm of 4-NPA to 4-nitrophenylate ion over a period of 3 min at 25°C using a spect... | J Enzyme Inhib Med Chem 28: 412-7 (2013) Article DOI: 10.3109/14756366.2011.651464 BindingDB Entry DOI: 10.7270/Q2W66JQ2 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Carbonic anhydrase 4 (Homo sapiens (Human)) | BDBM23417 (α-CA inhibitor, 4 | (-)-Epicatechin | (2R,3R)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 3.98E+3 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Ege University | Assay Description CA activity was assayed by following the change in absorbance at 348 nm of 4-NPA to 4-nitrophenylate ion over a period of 3 min at 25°C using a spect... | J Enzyme Inhib Med Chem 28: 412-7 (2013) Article DOI: 10.3109/14756366.2011.651464 BindingDB Entry DOI: 10.7270/Q2W66JQ2 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Carbonic anhydrase 6 (CA-VI) (Homo sapiens (Human)) | BDBM23417 (α-CA inhibitor, 4 | (-)-Epicatechin | (2R,3R)...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 4.36E+3 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Ege University | Assay Description CA activity was assayed by following the change in absorbance at 348 nm of 4-NPA to 4-nitrophenylate ion over a period of 3 min at 25°C using a spect... | J Enzyme Inhib Med Chem 28: 412-7 (2013) Article DOI: 10.3109/14756366.2011.651464 BindingDB Entry DOI: 10.7270/Q2W66JQ2 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Carbonic anhydrase 3 (CA III) (Bos taurus (Cattle)) | BDBM23417 (α-CA inhibitor, 4 | (-)-Epicatechin | (2R,3R)...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 8.93E+3 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Ege University | Assay Description CA activity was assayed by following the change in absorbance at 348 nm of 4-NPA to 4-nitrophenylate ion over a period of 3 min at 25°C using a spect... | J Enzyme Inhib Med Chem 28: 412-7 (2013) Article DOI: 10.3109/14756366.2011.651464 BindingDB Entry DOI: 10.7270/Q2W66JQ2 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Alpi (Rattus norvegicus (Rat)) | BDBM23417 (α-CA inhibitor, 4 | (-)-Epicatechin | (2R,3R)...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | 1.36E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C... | PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2DB809V | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mitogen-activated protein kinase 14 (Homo sapiens (Human)) | BDBM23417 (α-CA inhibitor, 4 | (-)-Epicatechin | (2R,3R)...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 6.76E+4 | n/a | n/a | n/a | n/a | n/a | 37 |
Eberhard Karls University of Tuebingen | Assay Description The p38alpha reaction was carried out by using kinase (12ng per well), ATP (100uM) and incubated for 60 min at 37 C. For the JNK3 assay, kinase (10n... | Chembiochem 11: 2579-88 (2010) Article DOI: 10.1002/cbic.201000487 BindingDB Entry DOI: 10.7270/Q21C1VDT | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mitogen-activated protein kinase 10 (Homo sapiens (Human)) | BDBM23417 (α-CA inhibitor, 4 | (-)-Epicatechin | (2R,3R)...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 8.95E+4 | n/a | n/a | n/a | n/a | n/a | 37 |
Eberhard Karls University of Tuebingen | Assay Description The p38alpha reaction was carried out by using kinase (12ng per well), ATP (100uM) and incubated for 60 min at 37 C. For the JNK3 assay, kinase (10n... | Chembiochem 11: 2579-88 (2010) Article DOI: 10.1002/cbic.201000487 BindingDB Entry DOI: 10.7270/Q21C1VDT | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Prothrombin (Homo sapiens (Human)) | BDBM23417 (α-CA inhibitor, 4 | (-)-Epicatechin | (2R,3R)...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 5.20 | n/a | n/a | n/a | n/a | n/a |
University of Lodz Curated by ChEMBL | Assay Description Inhibition of human thrombin assessed as equilibrium dissociation constant at 50 to 1000 uM by BIAcore analysis | Med Chem Res 23: 2324-2337 (2014) Article DOI: 10.1007/s00044-013-0829-4 BindingDB Entry DOI: 10.7270/Q2377B7W | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Prothrombin (Homo sapiens (Human)) | BDBM23417 (α-CA inhibitor, 4 | (-)-Epicatechin | (2R,3R)...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.50E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Lodz Curated by ChEMBL | Assay Description Inhibition of human thrombin amidolytic activity using D-Phe-Pip-Arg-pNA as substrate preincubated for 10 mins followed by substrate addition measure... | Med Chem Res 23: 2324-2337 (2014) Article DOI: 10.1007/s00044-013-0829-4 BindingDB Entry DOI: 10.7270/Q2377B7W | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Prostaglandin G/H synthase (cyclooxygenase) (Ovis aries (Sheep)) | BDBM23417 (α-CA inhibitor, 4 | (-)-Epicatechin | (2R,3R)...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 2.59E+4 | n/a | n/a | n/a | n/a | n/a |
University of Pennsylvania School of Medicine Curated by ChEMBL | Assay Description Binding affinity to COX1 in sheep seminal vesicle | J Nat Prod 67: 1777-82 (2004) Article DOI: 10.1021/np0498410 BindingDB Entry DOI: 10.7270/Q2XD12JH | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Prostaglandin G/H synthase (cyclooxygenase) (Ovis aries (Sheep)) | BDBM23417 (α-CA inhibitor, 4 | (-)-Epicatechin | (2R,3R)...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.22E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pennsylvania School of Medicine Curated by ChEMBL | Assay Description Inhibition of cyclooxygenase activity of COX1 in sheep seminal vesicle in presence of 1 mM phenol by cyclooxygenase assay | J Nat Prod 67: 1777-82 (2004) Article DOI: 10.1021/np0498410 BindingDB Entry DOI: 10.7270/Q2XD12JH | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1) | BDBM23417 (α-CA inhibitor, 4 | (-)-Epicatechin | (2R,3R)...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toledo Curated by ChEMBL | Assay Description Inhibition of polymerization in wild type HIV-1 RT with poly rC/dG12-18 template primer and [3H]dGTP | Bioorg Med Chem Lett 11: 2763-7 (2001) BindingDB Entry DOI: 10.7270/Q2X92BTR | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 6-phosphogluconate dehydrogenase (6PGD) (Homo sapiens (Human)) | BDBM23417 (α-CA inhibitor, 4 | (-)-Epicatechin | (2R,3R)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
AmorePacific Corporation Curated by ChEMBL | Assay Description Inhibition of 6PGD | Bioorg Med Chem 16: 3580-6 (2008) Article DOI: 10.1016/j.bmc.2008.02.030 BindingDB Entry DOI: 10.7270/Q2F190K1 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucose-6-phosphate 1-dehydrogenase (Saccharomyces cerevisiae S288c) | BDBM23417 (α-CA inhibitor, 4 | (-)-Epicatechin | (2R,3R)...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
AmorePacific Corporation Curated by ChEMBL | Assay Description Inhibition of yeast G6PD | Bioorg Med Chem 16: 3580-6 (2008) Article DOI: 10.1016/j.bmc.2008.02.030 BindingDB Entry DOI: 10.7270/Q2F190K1 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Fatty acid synthase (Homo sapiens (Human)) | BDBM23417 (α-CA inhibitor, 4 | (-)-Epicatechin | (2R,3R)...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Research Institute of Bioscience and Biotechnology Curated by ChEMBL | Assay Description Inhibition of FAS | Bioorg Med Chem Lett 16: 4738-42 (2006) Article DOI: 10.1016/j.bmcl.2006.07.018 BindingDB Entry DOI: 10.7270/Q2QV3NB7 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| alpha-Glucosidase (α-Glucosidase) (Rattus norvegicus (Rat)) | BDBM23417 (α-CA inhibitor, 4 | (-)-Epicatechin | (2R,3R)...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 6.50E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Chungnam National University Curated by ChEMBL | Assay Description Inhibition of rat intestinal sucrase using p-nitrophenyl-alpha-d-glucopyranoside as substrate incubated for 10 mins prior to substrate addition measu... | Bioorg Med Chem Lett 24: 1192-6 (2014) Article DOI: 10.1016/j.bmcl.2013.12.098 BindingDB Entry DOI: 10.7270/Q2TM7CMJ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Arginase (Leishmania amazonensis) | BDBM23417 (α-CA inhibitor, 4 | (-)-Epicatechin | (2R,3R)...) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade Federal de S£o Carlos Curated by ChEMBL | Assay Description Inhibition of Leishmania amazonensis recombinant arginase expressed in Escherichia coli Rosetta (DE3) pLysS using L-arginine as substrate incubated f... | J Nat Prod 77: 392-6 (2014) Article DOI: 10.1021/np400717m BindingDB Entry DOI: 10.7270/Q2VX0J09 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Aldose reductase (Rattus norvegicus) | BDBM23417 (α-CA inhibitor, 4 | (-)-Epicatechin | (2R,3R)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of aldose reductase in rat lens homogenate | J Nat Prod 66: 1191-6 (2003) Article DOI: 10.1021/np0301543 BindingDB Entry DOI: 10.7270/Q2PV6M79 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| DNA polymerase beta (Rattus norvegicus) | BDBM23417 (α-CA inhibitor, 4 | (-)-Epicatechin | (2R,3R)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.85E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia Curated by ChEMBL | Assay Description Inhibition of lyase activity of rat DNA polymerase beta after 30 mins by deoxyribose phosphate excision assay | J Nat Prod 67: 1744-7 (2004) Article DOI: 10.1021/np040057p BindingDB Entry DOI: 10.7270/Q2251K28 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Prostaglandin G/H synthase (cyclooxygenase) (Ovis aries (Sheep)) | BDBM23417 (α-CA inhibitor, 4 | (-)-Epicatechin | (2R,3R)...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pennsylvania School of Medicine Curated by ChEMBL | Assay Description Inhibition of peroxidase activity of COX1 in heep seminal vesicle by TMPD assay | J Nat Prod 67: 1777-82 (2004) Article DOI: 10.1021/np0498410 BindingDB Entry DOI: 10.7270/Q2XD12JH | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Xanthine dehydrogenase/oxidase (Homo sapiens (Human)) | BDBM23417 (α-CA inhibitor, 4 | (-)-Epicatechin | (2R,3R)...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp Curated by ChEMBL | Assay Description Inhibition of xanthine oxidase assessed as decrease in uric acid production by spectrophotometry | J Nat Prod 61: 71-6 (1998) Article DOI: 10.1021/np970237h BindingDB Entry DOI: 10.7270/Q29C6Z93 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Alkaline phosphatase, tissue-nonspecific isozyme (Homo sapiens (Human)) | BDBM23417 (α-CA inhibitor, 4 | (-)-Epicatechin | (2R,3R)...) | KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | 407 | n/a | n/a | n/a | n/a | n/a | n/a |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C... | PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2H130G1 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Alkaline phosphatase placental-like (Homo sapiens (Human)) | BDBM23417 (α-CA inhibitor, 4 | (-)-Epicatechin | (2R,3R)...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | n/a | 5.13E+4 | n/a | n/a | n/a | n/a |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C... | PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2SJ1J25 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Intestinal alkaline phosphatase (Homo sapiens (Human)) | BDBM23417 (α-CA inhibitor, 4 | (-)-Epicatechin | (2R,3R)...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | Purchase KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C... | PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q29G5K8R | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Procathepsin L (Homo sapiens (Human)) | BDBM23417 (α-CA inhibitor, 4 | (-)-Epicatechin | (2R,3R)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | >5.96E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute Molecular Screening Center Curated by PubChem BioAssay | Assay Description Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: The Scripps Research Institute, TSRI Assay Provide... | PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q20K2704 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| M18 aspartyl aminopeptidase (Plasmodium falciparum 3D7) | BDBM23417 (α-CA inhibitor, 4 | (-)-Epicatechin | (2R,3R)...) | PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | 1.38E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute Molecular Screening Center Curated by PubChem BioAssay | Assay Description Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: The Scripps Research Institute, TSRI Assay Provide... | PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q24B2ZQ2 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Anthrax toxin receptor 2 (Homo sapiens) | BDBM23417 (α-CA inhibitor, 4 | (-)-Epicatechin | (2R,3R)...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description Inhibition of CMG2 (40 to 217) C175A and R40C double mutant (unknown origin) interaction to full length PA E733C mutant expressed in Escherichia coli... | J Med Chem 56: 1940-5 (2013) Article DOI: 10.1021/jm301558t BindingDB Entry DOI: 10.7270/Q2BP05Q3 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nitric Oxide Synthase, endothelial (Bos taurus (bovine)) | BDBM23417 (α-CA inhibitor, 4 | (-)-Epicatechin | (2R,3R)...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 2 | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Activation of eNOS in BCAEC assessed as increase in nitric oxide level after 10 mins by fluorometric analysis | Bioorg Med Chem Lett 23: 4441-6 (2013) Article DOI: 10.1016/j.bmcl.2013.05.079 BindingDB Entry DOI: 10.7270/Q2P84D93 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Alpha-amylase (Homo sapiens (Human)) | BDBM23417 (α-CA inhibitor, 4 | (-)-Epicatechin | (2R,3R)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | n/a | n/a | n/a | 6.0 | 22 |
Nestle Research Center | Assay Description The assay was carried out at room temperature for 10 min with salivary alpha-amylase, starch, and test compounds. The reducing sugar was determined b... | J Med Chem 51: 3555-61 (2008) Article DOI: 10.1021/jm800115x BindingDB Entry DOI: 10.7270/Q237771Z | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
