BDBM23446 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one::CHEMBL45068::Phloretin::cid_4788
SMILES: Oc1ccc(CCC(=O)c2c(O)cc(O)cc2O)cc1
InChI Key: InChIKey=VGEREEWJJVICBM-UHFFFAOYSA-N
Data: 2 KI 11 IC50 1 EC50 6 ITC
PDB links: 3 PDB IDs match this monomer. 8 PDB IDs contain this monomer as substructures. 8 PDB IDs contain inhibitors having a similarity of 90% to this monomer.
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Solute carrier family 28 member 3 (Homo sapiens (Human)) | BDBM23446 (3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)prop...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 3.23E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tennessee Health Sciences Center Curated by ChEMBL | Assay Description Binding affinity to human recombinant CNT3 expressed in pig PK15NTD cells assessed as [3H]uridine uptake by beta-scintillation counter | Bioorg Med Chem Lett 19: 917-21 (2009) Article DOI: 10.1016/j.bmcl.2008.11.112 BindingDB Entry DOI: 10.7270/Q2K07440 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/glucose cotransporter 1 (SGLT1) (Homo sapiens (Human)) | BDBM23446 (3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)prop...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | 8.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Max-Planck-Institut f£r molekulare Physiologie Curated by ChEMBL | Assay Description Binding affinity against Sodium/glucose co-transporter of isolated renal brush border membranes. | J Med Chem 43: 1692-8 (2000) BindingDB Entry DOI: 10.7270/Q261112H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucose Transporter 1 (hGLUT1) (Homo sapiens (Human)) | BDBM23446 (3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)prop...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.14E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa Curated by ChEMBL | Assay Description Inhibition of GLUT1 in human H1299 cells assessed as inhibition of 2-deoxy-D-[3H]-glucose uptake incubated for 15 mins prior to 2-deoxy-D-[3H]-glucos... | Bioorg Med Chem Lett 23: 6923-7 (2013) Article DOI: 10.1016/j.bmcl.2013.09.037 BindingDB Entry DOI: 10.7270/Q2639R6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Monocarboxylate transporter 2 (Rattus norvegicus) | BDBM23446 (3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)prop...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Physiologisch-chemisches Institut der Eberhard-Karls-Universit£t T£bingen Curated by ChEMBL | Assay Description TP_TRANSPORTER: inhibition of lactate uptake in Xenopus laevis oocytes | Biochem J 341: 529-35 (1999) BindingDB Entry DOI: 10.7270/Q2125TQV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Monocarboxylate transporter 4 (Homo sapiens (Human)) | BDBM23446 (3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)prop...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 4.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bristol Curated by ChEMBL | Assay Description TP_TRANSPORTER: inhibition of L-Lactate uptake (L-Lactate:30mM) in Xenopus laevis oocytes | J Physiol (Lond) 529: 285-93 (2000) Article DOI: 10.1111/j.1469-7793.2000.00285.x BindingDB Entry DOI: 10.7270/Q2WM1H9H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/glucose cotransporter 2 (Homo sapiens (Human)) | BDBM23446 (3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)prop...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.83E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade de Lisboa Curated by ChEMBL | Assay Description Inhibition of human SGLT2 expressed in HEK293 cells assessed as reduction in 2-deoxyglucose uptake pretreated for 10 mins followed by 2-deoxyglucose ... | J Med Chem 60: 568-579 (2017) Article DOI: 10.1021/acs.jmedchem.6b01134 BindingDB Entry DOI: 10.7270/Q2KK9F2F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/glucose cotransporter 1 (SGLT1) (Homo sapiens (Human)) | BDBM23446 (3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)prop...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.24E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade de Lisboa Curated by ChEMBL | Assay Description Inhibition of human SGLT1 expressed in HEK293 cells assessed as reduction in 2-deoxyglucose uptake pretreated for 10 mins followed by 2-deoxyglucose ... | J Med Chem 60: 568-579 (2017) Article DOI: 10.1021/acs.jmedchem.6b01134 BindingDB Entry DOI: 10.7270/Q2KK9F2F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pancreatic triacylglycerol lipase (Sus scrofa (Pig)) | BDBM23446 (3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)prop...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 5.04E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Department of Food Science and Biotechnology, Daegu University, Gyeongsan 38453, Republic of Korea. Curated by ChEMBL | Assay Description Inhibition of porcine pancreatic lipase using p-nitrophenyl butyrate as substrate pretreated for 15 mins followed by substrate addition measured afte... | Bioorg Med Chem Lett 27: 4889-4892 (2017) Article DOI: 10.1016/j.bmcl.2017.09.035 BindingDB Entry DOI: 10.7270/Q23J3GFT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-chymotrypsin (Bos taurus (bovine)) | BDBM23446 (3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)prop...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University Curated by ChEMBL | Assay Description Inhibition of alpha-chymotrypsin in bovine pancreas using SPpNA as substrate pretreated with enzyme for 30 mins followed by substrate addition and me... | ACS Med Chem Lett 10: 923-928 (2019) Article DOI: 10.1021/acsmedchemlett.9b00093 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Enterobacter cloacae) | BDBM23446 (3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)prop...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 4.96E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University Curated by ChEMBL | Assay Description Inhibition of Enterobacter cloacae beta-lactamase incubated for 10 mins followed by nitrocefin substrate challenge and measured for 5 mins by spectro... | ACS Med Chem Lett 10: 923-928 (2019) Article DOI: 10.1021/acsmedchemlett.9b00093 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Topoisomerase I/II (Homo sapiens (Human)) | BDBM23446 (3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)prop...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.67E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Illinois at Chicago Curated by ChEMBL | Assay Description Inhibition of human DNA topoisomerase 2 catalytic domain-mediated knotted bacteriophage P4Virl dell0 DNA unknotting by agarose gel electrophoresis | J Nat Prod 58: 217-25 (1995) Article DOI: 10.1021/np50116a009 BindingDB Entry DOI: 10.7270/Q2SQ936B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM23446 (3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)prop...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.50E+7 | n/a | n/a | n/a | n/a | n/a | n/a |
Griffith University Curated by ChEMBL | Assay Description Inhibition of EGFR | J Nat Prod 69: 14-7 (2006) Article DOI: 10.1021/np050229y BindingDB Entry DOI: 10.7270/Q2FJ2GHF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase 33 (Homo sapiens (Human)) | BDBM23446 (3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)prop...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | n/a | 2.14E+4 | n/a | n/a | n/a | n/a |
Broad Institute Curated by PubChem BioAssay | Assay Description Keywords: STK33 Kinase, Non-ATP Competitive Inhibitor Assay Overview: Purified STK33 Kinase is preincubated with potential inhibitors and allowed to ... | PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2B27SRF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Monocarboxylate transporter 1 (MCT1) (Rattus norvegicus (Rat)) | BDBM23446 (3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)prop...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 2.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Physiologisch-chemisches Institut der Eberhard-Karls-Universit£t T£bingen Curated by ChEMBL | Assay Description TP_TRANSPORTER: inhibition of lactate uptake in Xenopus laevis oocytes | Biochem J 341: 529-35 (1999) BindingDB Entry DOI: 10.7270/Q2125TQV | |||||||||||
More data for this Ligand-Target Pair |
Cell (A) | Syringe (B) | Cell Links | Syringe Links | Cell + Syr Links | ΔG° kcal/mole | -TΔS° kcal/mole | ΔH° kcal/mole | log K | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|
Transcriptional Regulator TtgR (Pseudomonas putida) | BDBM23446 (3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)prop...) | GoogleScholar PDB | CHEBI DrugBank KEGG MMDB PC cid PC sid PDB | -10.2 | 4.89 | -15.1 | 7.32 | 7 | 30 | |
Imperial College London | J Mol Biol 369: 829-40 (2007) | |||||||||
Transcriptional Regulator TtgR (Pseudomonas putida) | BDBM23446 (3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)prop...) | GoogleScholar PDB | CHEBI DrugBank KEGG MMDB PC cid PC sid PDB | -8.29 | 8.70 | -17.0 | 5.99 | 7 | 30 | |
Estacion Experimental del Zaidin | J Biol Chem 281: 7102-9 (2006) | |||||||||
Transcriptional Regulator TtgR Mutant R176G (Pseudomonas putida) | BDBM23446 (3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)prop...) | GoogleScholar PDB | CHEBI DrugBank KEGG MMDB PC cid PC sid PDB | -6.99 | 14.6 | -21.6 | 5.04 | 7 | 30 | |
Imperial College London | J Mol Biol 369: 829-40 (2007) | |||||||||
Transcriptional Regulator TtgR (Pseudomonas putida) | BDBM23446 (3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)prop...) | GoogleScholar PDB | CHEBI DrugBank KEGG MMDB PC cid PC sid PDB | -8.25 | 7.43 | -15.7 | 5.95 | 7 | 30 | |
Estacion Experimental del Zaidin | J Biol Chem 281: 7102-9 (2006) | |||||||||
Transcriptional Regulator TtgR-DNA (Pseudomonas putida) | BDBM23446 (3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)prop...) | GoogleScholar PDB | CHEBI DrugBank KEGG MMDB PC cid PC sid PDB | -8.74 | 10.4 | -19.2 | 6.31 | 7 | 30 | |
Estacion Experimental del Zaidin | J Biol Chem 281: 7102-9 (2006) | |||||||||
Transcriptional Regulator TtgR (Pseudomonas putida) | BDBM23446 (3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)prop...) | GoogleScholar PDB | CHEBI DrugBank KEGG MMDB PC cid PC sid PDB | -6.87 | -4.88 | -1.99 | 4.96 | 7 | 30 | |
Estacion Experimental del Zaidin | J Biol Chem 281: 7102-9 (2006) |