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SMILES: COc1ccc(cc1)C1(NC(=N)N(CC2CCN(CC2)C(=O)OC(C)(C)C)C1=O)c1ccc(OC)cc1
InChI Key: InChIKey=FHVISDKTJAQQPR-UHFFFAOYSA-N
| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Beta-secretase 1 (Homo sapiens (Human)) | BDBM234549 (US9353089, 313) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet  | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | 4.0 | 25 |
Saint Louis University; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences US Patent | Assay Description The recombinant human BACE1, Cathepsin D, and Cathepsin E enzymes were purchased from R&D Systems (catalog numbers are 931-AS, 1014AS and 1294AS, res... | US Patent US9353089 (2016) BindingDB Entry DOI: 10.7270/Q2GQ6WP6 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Plasmepsin II (Plasmodium falciparum) | BDBM234549 (US9353089, 313) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 11 | n/a | n/a | n/a | n/a | 4.5 | 25 |
Saint Louis University; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences US Patent | Assay Description Plasmepsin-2 (PM-2; Plm II) and Plasmepsin (PM-4; Plm IV) expression and purification was performed following the published protocols (Istvan E S and... | US Patent US9353089 (2016) BindingDB Entry DOI: 10.7270/Q2GQ6WP6 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
