BDBM23455 (1R,2R)-1-N-hydroxy-2-{3-[(2-methylquinolin-4-yl)methoxy]phenyl}cyclopropane-1,2-dicarboxamide::hydroxamate deriv., 29
SMILES: Cc1cc(COc2cccc(c2)[C@]2(C[C@H]2C(=O)NO)C(N)=O)c2ccccc2n1
InChI Key: InChIKey=LOEOATDRPRNXBR-AVRDEDQJSA-N
Data: 1 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Disintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q] (Homo sapiens (Human)) | BDBM23455 ((1R,2R)-1-N-hydroxy-2-{3-[(2-methylquinolin-4-yl)m...) | PDB MMDB B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | 700 | -8.31 | n/a | n/a | n/a | n/a | n/a | 7.3 | 22 |
Schering-Plough Research Institute | Assay Description Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ... | J Med Chem 51: 725-36 (2008) Article DOI: 10.1021/jm070376o BindingDB Entry DOI: 10.7270/Q2Q23XKR | |||||||||||
More data for this Ligand-Target Pair |