BDBM23470 hydroxamate deriv., 62::methyl (1R,2R)-1-[3-(2-{3-[(1Z)-buta-1,3-dien-1-yl]phenyl}ethoxy)phenyl]-2-(hydroxycarbamoyl)cyclopropane-1-carboxylate

SMILES: COC(=O)[C@@]1(C[C@H]1C(=O)NO)c1cccc(OCCc2cccc(\C=C/C=C)c2)c1

InChI Key: InChIKey=YDDKZUMXWMGFOP-FSCAMMEHSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 23470   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
TNF-alpha-Converting Enzyme (Homo sapiens (Human))	BDBM23470 (hydroxamate deriv., 62 | methyl (1R,2R)-1-[3-(2-{3...) Show SMILES COC(=O)[C@@]1(C[C@H]1C(=O)NO)c1cccc(OCCc2cccc(\C=C/C=C)c2)c1 |r| Show InChI InChI=1S/C24H25NO5/c1-3-4-7-17-8-5-9-18(14-17)12-13-30-20-11-6-10-19(15-20)24(23(27)29-2)16-21(24)22(26)25-28/h3-11,14-15,21,28H,1,12-13,16H2,2H3,(H,25,26)/b7-4-/t21-,24-/m0/s1	PDB MMDB B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	50	-9.85	n/a	n/a	n/a	n/a	n/a	7.3	22
Schering-Plough Research Institute					Assay Description Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...				J Med Chem 51: 725-36 (2008) Article DOI: 10.1021/jm070376o BindingDB Entry DOI: 10.7270/Q2Q23XKR
					More data for this Ligand-Target Pair