BDBM23484 CHEMBL410462::hydroxamate deriv., 34::methyl (1R,2S)-2-(hydroxycarbamoyl)-1-({4-[(2-methylquinolin-4-yl)methoxy]phenyl}methyl)cyclopropane-1-carboxylate
SMILES: COC(=O)[C@@]1(Cc2ccc(OCc3cc(C)nc4ccccc34)cc2)C[C@@H]1C(=O)NO
InChI Key: InChIKey=HJWMYFBKJRVWJY-YKSBVNFPSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human)) | BDBM23484 (CHEMBL410462 | hydroxamate deriv., 34 | methyl (1R...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank MMDB PDB Article PubMed | 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Athens Curated by ChEMBL | Assay Description Inhibition of TACE | Bioorg Med Chem 16: 8781-94 (2008) Article DOI: 10.1016/j.bmc.2008.08.058 BindingDB Entry DOI: 10.7270/Q2JD4WM2 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
TNF-alpha-Converting Enzyme (Homo sapiens (Human)) | BDBM23484 (CHEMBL410462 | hydroxamate deriv., 34 | methyl (1R...) | PDB MMDB B.MOAD GoogleScholar AffyNet | CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute | Assay Description Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ... | J Med Chem 51: 725-36 (2008) Article DOI: 10.1021/jm070376o BindingDB Entry DOI: 10.7270/Q2Q23XKR | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |