BDBM23518 2-[3-(naphthalen-2-yl)propanamido]benzoic acid::Biaryl Anthranilide Analogue, 1b::CHEMBL235740
SMILES: OC(=O)c1ccccc1NC(=O)CCc1ccc2ccccc2c1
InChI Key: InChIKey=TUCHRHOVXUFQLY-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Hydroxycarboxylic acid receptor 2 (Homo sapiens (Human)) | BDBM23518 (2-[3-(naphthalen-2-yl)propanamido]benzoic acid | B...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 140 | n/a | 1.00E+3 | n/a | n/a | 7.4 | 23 |
Merck Research Laboratories | Assay Description Membranes were incubated in binding buffer with [5, 6-3H]-niacin in the presence of test compound. After 4 hours at room temperature, reactions were ... | J Med Chem 50: 6303-6 (2007) Article DOI: 10.1021/jm700942d BindingDB Entry DOI: 10.7270/Q29S1PBG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hydroxycarboxylic acid receptor 2 (Homo sapiens (Human)) | BDBM23518 (2-[3-(naphthalen-2-yl)propanamido]benzoic acid | B...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 500 | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay | J Med Chem 52: 2587-602 (2009) Article DOI: 10.1021/jm900151e BindingDB Entry DOI: 10.7270/Q2RJ4JDG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hydroxycarboxylic acid receptor 2 (Homo sapiens (Human)) | BDBM23518 (2-[3-(naphthalen-2-yl)propanamido]benzoic acid | B...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Agonist activity at human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS guanine nucleotide exchange assay | Bioorg Med Chem Lett 18: 4963-7 (2008) Article DOI: 10.1016/j.bmcl.2008.08.030 BindingDB Entry DOI: 10.7270/Q2V124M6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hydroxycarboxylic acid receptor 2 (Homo sapiens (Human)) | BDBM23518 (2-[3-(naphthalen-2-yl)propanamido]benzoic acid | B...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Displacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO-K1 cells | Bioorg Med Chem Lett 18: 4963-7 (2008) Article DOI: 10.1016/j.bmcl.2008.08.030 BindingDB Entry DOI: 10.7270/Q2V124M6 | |||||||||||
More data for this Ligand-Target Pair |