BDBM23551 3-Carboxamide-coumarin deriv., 48::5-oxo-N-phenyl-6-oxatricyclo[8.4.0.0^{2,7}]tetradeca-1(10),2(7),3,8,11,13-hexaene-4-carboxamide

SMILES: O=C(Nc1ccccc1)c1cc2c(ccc3ccccc23)oc1=O

InChI Key: InChIKey=KGKLIFKFUPGIEE-UHFFFAOYSA-N

Data: 1 Other

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 23551   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Factor XIIa (Homo sapiens (Human))	BDBM23551 (3-Carboxamide-coumarin deriv., 48 | 5-oxo-N-phenyl...) Show SMILES O=C(Nc1ccccc1)c1cc2c(ccc3ccccc23)oc1=O Show InChI InChI=1S/C20H13NO3/c22-19(21-14-7-2-1-3-8-14)17-12-16-15-9-5-4-6-13(15)10-11-18(16)24-20(17)23/h1-12H,(H,21,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	n/a	n/a	n/a	7.9	22
University of Namur					Assay Description After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...				J Med Chem 51: 3077-80 (2008) Article DOI: 10.1021/jm8002697 BindingDB Entry DOI: 10.7270/Q2610XNH
					More data for this Ligand-Target Pair