Found 5 hits for monomerid = 235742 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
cGMP-specific 3',5'-cyclic phosphodiesterase [537-875]
(Homo sapiens (Human)) | BDBM235742
(US9359371, 11)Show SMILES COc1ccc(CNc2nc(ncc2C(=O)N[C@H]2CC[C@H](O)CC2)N2CC3CC3C2)cc1Cl |r,wU:17.17,wD:20.21,(-9.38,-3.8,;-8.05,-4.57,;-6.72,-3.8,;-5.33,-4.55,;-4,-3.78,;-4,-2.24,;-2.67,-1.47,;-1.33,-2.24,;,-1.47,;,.07,;1.33,.84,;2.67,.07,;2.67,-1.47,;1.33,-2.24,;1.33,-3.78,;,-4.55,;2.67,-4.55,;4,-3.78,;4,-2.24,;5.33,-1.47,;6.67,-2.24,;8,-1.47,;6.67,-3.78,;5.33,-4.55,;1.33,2.38,;2.58,3.29,;2.1,4.75,;1.33,6.09,;.56,4.75,;.09,3.29,;-5.33,-1.47,;-6.67,-2.24,;-8,-1.47,)| Show InChI InChI=1S/C24H30ClN5O3/c1-33-21-7-2-14(8-20(21)25)10-26-22-19(23(32)28-17-3-5-18(31)6-4-17)11-27-24(29-22)30-12-15-9-16(15)13-30/h2,7-8,11,15-18,31H,3-6,9-10,12-13H2,1H3,(H,28,32)(H,26,27,29)/t15?,16?,17-,18- | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 4.02 | n/a | n/a | n/a | n/a | 7.5 | n/a |
XUANZHU PHARMA CO., LTD.
US Patent
| Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio... |
US Patent US9359371 (2016)
BindingDB Entry DOI: 10.7270/Q2BR8R2B |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase [537-875]
(Homo sapiens (Human)) | BDBM235742
(US9359371, 11)Show SMILES COc1ccc(CNc2nc(ncc2C(=O)N[C@H]2CC[C@H](O)CC2)N2CC3CC3C2)cc1Cl |r,wU:17.17,wD:20.21,(-9.38,-3.8,;-8.05,-4.57,;-6.72,-3.8,;-5.33,-4.55,;-4,-3.78,;-4,-2.24,;-2.67,-1.47,;-1.33,-2.24,;,-1.47,;,.07,;1.33,.84,;2.67,.07,;2.67,-1.47,;1.33,-2.24,;1.33,-3.78,;,-4.55,;2.67,-4.55,;4,-3.78,;4,-2.24,;5.33,-1.47,;6.67,-2.24,;8,-1.47,;6.67,-3.78,;5.33,-4.55,;1.33,2.38,;2.58,3.29,;2.1,4.75,;1.33,6.09,;.56,4.75,;.09,3.29,;-5.33,-1.47,;-6.67,-2.24,;-8,-1.47,)| Show InChI InChI=1S/C24H30ClN5O3/c1-33-21-7-2-14(8-20(21)25)10-26-22-19(23(32)28-17-3-5-18(31)6-4-17)11-27-24(29-22)30-12-15-9-16(15)13-30/h2,7-8,11,15-18,31H,3-6,9-10,12-13H2,1H3,(H,28,32)(H,26,27,29)/t15?,16?,17-,18- | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.31 | n/a | n/a | n/a | n/a | 7.5 | n/a |
XUANZHU PHARMA CO., LTD.
US Patent
| Assay Description
The test compound or solvent was incubated at 25° C. for 15 min with enzyme solution (35 μg/mL) in Tris-HCl buffer of pH 7.5. 1 μM cGMP and... |
US Patent US9359371 (2016)
BindingDB Entry DOI: 10.7270/Q2BR8R2B |
More data for this
Ligand-Target Pair | |
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
(Homo sapiens (Human)) | BDBM235742
(US9359371, 11)Show SMILES COc1ccc(CNc2nc(ncc2C(=O)N[C@H]2CC[C@H](O)CC2)N2CC3CC3C2)cc1Cl |r,wU:17.17,wD:20.21,(-9.38,-3.8,;-8.05,-4.57,;-6.72,-3.8,;-5.33,-4.55,;-4,-3.78,;-4,-2.24,;-2.67,-1.47,;-1.33,-2.24,;,-1.47,;,.07,;1.33,.84,;2.67,.07,;2.67,-1.47,;1.33,-2.24,;1.33,-3.78,;,-4.55,;2.67,-4.55,;4,-3.78,;4,-2.24,;5.33,-1.47,;6.67,-2.24,;8,-1.47,;6.67,-3.78,;5.33,-4.55,;1.33,2.38,;2.58,3.29,;2.1,4.75,;1.33,6.09,;.56,4.75,;.09,3.29,;-5.33,-1.47,;-6.67,-2.24,;-8,-1.47,)| Show InChI InChI=1S/C24H30ClN5O3/c1-33-21-7-2-14(8-20(21)25)10-26-22-19(23(32)28-17-3-5-18(31)6-4-17)11-27-24(29-22)30-12-15-9-16(15)13-30/h2,7-8,11,15-18,31H,3-6,9-10,12-13H2,1H3,(H,28,32)(H,26,27,29)/t15?,16?,17-,18- | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
XUANZHU PHARMA CO., LTD.
US Patent
| Assay Description
To a 96-well plate, 20 μL of 10 μM FL-cGMP as the substrate was added; then 1 μL solution of the compound in DMSO or DMSO solution wit... |
US Patent US9359371 (2016)
BindingDB Entry DOI: 10.7270/Q2BR8R2B |
More data for this
Ligand-Target Pair | |
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
(Bos taurus (Bovine)) | BDBM235742
(US9359371, 11)Show SMILES COc1ccc(CNc2nc(ncc2C(=O)N[C@H]2CC[C@H](O)CC2)N2CC3CC3C2)cc1Cl |r,wU:17.17,wD:20.21,(-9.38,-3.8,;-8.05,-4.57,;-6.72,-3.8,;-5.33,-4.55,;-4,-3.78,;-4,-2.24,;-2.67,-1.47,;-1.33,-2.24,;,-1.47,;,.07,;1.33,.84,;2.67,.07,;2.67,-1.47,;1.33,-2.24,;1.33,-3.78,;,-4.55,;2.67,-4.55,;4,-3.78,;4,-2.24,;5.33,-1.47,;6.67,-2.24,;8,-1.47,;6.67,-3.78,;5.33,-4.55,;1.33,2.38,;2.58,3.29,;2.1,4.75,;1.33,6.09,;.56,4.75,;.09,3.29,;-5.33,-1.47,;-6.67,-2.24,;-8,-1.47,)| Show InChI InChI=1S/C24H30ClN5O3/c1-33-21-7-2-14(8-20(21)25)10-26-22-19(23(32)28-17-3-5-18(31)6-4-17)11-27-24(29-22)30-12-15-9-16(15)13-30/h2,7-8,11,15-18,31H,3-6,9-10,12-13H2,1H3,(H,28,32)(H,26,27,29)/t15?,16?,17-,18- | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 61 | n/a | n/a | n/a | n/a | 7.5 | n/a |
XUANZHU PHARMA CO., LTD.
US Patent
| Assay Description
Method: The test compound or solvent was incubated at 25° C. for 15 min with enzyme solution (0.2 μg/mL) in Tris-HCl buffer of pH 7.5. 100 μ... |
US Patent US9359371 (2016)
BindingDB Entry DOI: 10.7270/Q2BR8R2B |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase [537-875]
(Homo sapiens (Human)) | BDBM235742
(US9359371, 11)Show SMILES COc1ccc(CNc2nc(ncc2C(=O)N[C@H]2CC[C@H](O)CC2)N2CC3CC3C2)cc1Cl |r,wU:17.17,wD:20.21,(-9.38,-3.8,;-8.05,-4.57,;-6.72,-3.8,;-5.33,-4.55,;-4,-3.78,;-4,-2.24,;-2.67,-1.47,;-1.33,-2.24,;,-1.47,;,.07,;1.33,.84,;2.67,.07,;2.67,-1.47,;1.33,-2.24,;1.33,-3.78,;,-4.55,;2.67,-4.55,;4,-3.78,;4,-2.24,;5.33,-1.47,;6.67,-2.24,;8,-1.47,;6.67,-3.78,;5.33,-4.55,;1.33,2.38,;2.58,3.29,;2.1,4.75,;1.33,6.09,;.56,4.75,;.09,3.29,;-5.33,-1.47,;-6.67,-2.24,;-8,-1.47,)| Show InChI InChI=1S/C24H30ClN5O3/c1-33-21-7-2-14(8-20(21)25)10-26-22-19(23(32)28-17-3-5-18(31)6-4-17)11-27-24(29-22)30-12-15-9-16(15)13-30/h2,7-8,11,15-18,31H,3-6,9-10,12-13H2,1H3,(H,28,32)(H,26,27,29)/t15?,16?,17-,18- | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.410 | n/a | n/a | n/a | n/a | 7.5 | n/a |
XUANZHU PHARMA CO., LTD.
US Patent
| Assay Description
The test compound or solvent was incubated at 25° C. for 15 min with enzyme solution (35 μg/mL) in Tris-HCl buffer of pH 7.5. 1 μM cGMP and... |
US Patent US9359371 (2016)
BindingDB Entry DOI: 10.7270/Q2BR8R2B |
More data for this
Ligand-Target Pair | |
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